Endocrine Abstracts

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

Introduction: Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor derived from C cells that is responsible for approximately 5% of the gland malignancies, most of them occuring sporadically. Lymph node metastasis may occur early in disease pathogenesis and is one of the most important negative prognostic factor. Surgery is the only curative therapy while other chemotherapeutic options are limited. Neuroendocrine differentiated C cells may express somatostat...

Introduction: There is evidence on the association of subacute thyroiditis (SAT) and SARS-CoV-2 infection, the first case report being described in a young woman back in July 2020 (1). Multisystemic inflammatory syndrome in adults (MIS-A) is a rare complication of SARS-CoV-2, usually 2 to 12 weeks after initial infection. The development of Graves disease after SAT is rare, with approximately 31 reported cases, of which only 5 occurring in men (2). We pre...

Introduction: There is evidence that SARS-COV-2 infection can result in development of endocrine disturbances. Expression of the angiotensin-converting enzyme 2, which is postulated to be at the center of the pathogenesis of COVID-19, has been reported in various endocrine tissues.Case Series: We retrospectively analyzed 12 patients with recent history of SARS-COV-2 infection: 5 cases with subacute thyroiditis (SAT), 2 cases with Graves’ disease, 2 ...

Introduction: While most of neuroendocrine tumors (NETs) primary sites are discovered, NETs of unknown primary are not entirely uncommon in the clinical setting. The primary site is a significant factor in terms of overall prognosis. The aim is to determine whether NETs of unknown primary site location (NET-USs) have more aggressive behavior than those with a known primary location. Matherials and Methods: We retrospectively studied 50 consecutive patien...

Upper extremity deep vein thrombosis (UEDVT) is not infrequent and accounts for approximately 14% of deep vein thrombosis. The risk of pulmonary embolism is lower than in lower extremity DVT and prompt diagnosis is essential to select those patients who deserve anticoagulant treatment. Previous studies indicated that type 2 diabetes (DM) patients carried greater risk of DVT development or recurrence than the general population.A 49-years old female, with...

Adult GH deficiency syndrome is characterized by visceral obesity, dyslipidemia, insulin resistance and is associated with an increased cardiovascular risk. Epicardial adipose tissue, giving its relationship with abdominal visceral adiposity, coronary artery disease, cardiac morphology and function and metabolic syndrome, has been proposed as cardio-metabolic risk indicator. In this study, we evaluated the echocardiographic epicardial fat thickness in 14 patients (8 M and 6 F,...

Introduction: Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, despite becoming evident only after puberty. The syndrome is characterized by a primary gonadal defect, which results in small testes due to hyalinization of the seminiferous tubules, low to low normal range of serum testosterone levels and elevated serum gonadotrophins. Paradoxically, a few cases have been described, presenting with hypogonadotropism.Case-repor...

Background: End stage renal disease is usually associated with high serum parathyroid hormone (PTH) and increased bone turnover. The aim of our study was to correlate serum PTH with serum markers of bone turnover in patients with end stage renal disease (ESRD).Methods: We measured serum PTH, osteocalcin, procollagen type 1 n-terminal propeptide (P1NP) and beta-crosslaps in 64 (32 men) consecutive pacients, median (25, 75 percentile) age 61 (49.5, 65.5) y...

Proton nuclear magnetic resonance spectroscopy (1H-NMR) was applied to investigate metabolic profile of type 2 diabetes mellitus (T2DM) patients and identify possible disorders of T2DM.We investigate the potential relationship between diabetic retinopathy (DR), diabetic neuropathy (DN), estimated glomerular filtration rate (eGFR), anthropometric indicators (body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), waist to sta...