Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep351 | Clinical case reports - Thyroid/Others | ECE2016

Saint John’s wort not so saint

Leon Claudia Arnas , Suarez Ana Delia Santana , Arroyo Sara Quintana , Calero Carmen Acosta , Martin Francisco Javier Martinez

Introduction: In addition to the medication prescribed by their doctors, patients may recourse to natural medicine and take herbal medications without thinking about their potential side effects and interactions with other drugs.Case Report: A 39-year-old female, with personal history of iron deficiency anemia, regular menses but long-standing dysmenorrhea and polymenorrhea and reactive anxiety-depressive disorder, complained of frequent intermenstrual s...

ea0090p533 | Late-Breaking | ECE2023

St. John’s wort as an example of the naturalistic fallacy: natural things are not necessarily good things

Rios-Gomez Carlos , Hernandez-Lazaro Alba , Jose de Leon-Durango Ricardo , Santana-Ojeda Borja , Arnas-Leon Claudia , Kuzior Agnieszka , Acosta-Calero Carmen , del Pino Ortiz-Hernandez Catherine , Maria Perez-Rivero Jennifer , Javier Martinez Martin Francisco

Introduction/Aim: New oral anticoagulant drugs such as the factor Xa inhibitor rivaroxaban are often preferred to the classic coumarins because they do not need frequent blood-test monitoring and have fever interactions with other drugs and foodstuffs. They are not, however, interaction free. Rivaroxaban is metabolized by oxidative degradation catalyzed by CYP3A4/5 and CYP2J2; it is also a substrate of the P-gp and ABCG2 efflux transporter proteins. CYP3A4 activity enhancers s...

ea0003p75 | Cytokines and Growth Factors | BES2002

Ischemia/reperfusion-induced leukocyte-endothelium interactions in the colon: Importance of P-selectin, CXC chemokines

Riaz A , Wan M , Dawson P , Jeppsson B , Thorlacius H

IntroductionLeukocyte recruitment is a key feature in (I/R)-induced tissue injury. We have developed and validated a novel method to study molecular mechanisms of leukocyte-endothelium interactions in the colonic microcirculation in vivo by use of inverted intravital fluorescence microscopy.Methods & ResultsIn male C57/BL6 mice the superior mesenteric artery was occluded 30 min and leukocyte rolling and ...

ea0059mte10.1 | Service Improvements | SFEBES2018

GIRFT (Getting It Right First Time) for Endocrinology, NHS England John A. H. Wass, Professor of Endocrinology, University of Oxford and Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, United Kingdom

Wass John

The GIRFT (Getting It Right First Time) visits, about which we have consulted the membership of the Society for Endocrinology and had positive feedback from many members, have now started. We have done four pilots in Birmingham, Leicester, Oxford and York. The objectives are to try to introduce a quantitative approach to help demonstrate best practice. It will explore surgical outcome data and complication rates with regard to thyroid, parathyroid, adrenal, pituitary and neuro...

ea0011p578 | Neuroendocrinology and behaviour | ECE2006

The impact of hypothalamic-pituitary (h-p) irradiation on the TSH Bio/Immuno (B/I) ratio in the fed and fasting states

Darzy KH , Persani L , Borgato S , Beck-Peccoz P , Shalet SM

The TSH B/I ratio is normally reduced overnight and is substantially reduced in patients with overt central hypothyroidism due to h-p axis tumours before and after treatment. It is unknown if similar changes in the TSH B/I ratio in the absence of overt central hypothyroidism contribute to the increased TSH levels seen in cancer survivors who undergo h-p axis irradiation. Thus, we selected 9 patients with the highest TSH levels out of a previously reported cohort of 37 euthyroi...

ea0022p59 | Adrenal | ECE2010

QTc and P wave dispersion in patients with Cushing's syndrome

Bayram Nihal Akar , Ersoy Reyhan , Tuzun Dilek , Inancli Serap Soytac , Bozkurt Engin , Cakir Bekir

Introduction: The clinical implications of QTc and P wave dispersion in patients with Cushing’s syndrome have not been studied previously. In this study, we aimed to compare QTc dispersion and P wave dispersion in patients with Cushing’s syndrome and healthy subjects.Material and method: Sixteen patients with Cushing’s syndrome diagnosed on clinical, laboratory and imaging findings and 16 age and sex matched control subjects were included....

ea0020oc6.6 | Paediatric Endocrinology/Bone | ECE2009

Reduced selenoprotein P expression affects bone formation

Hog Antonia , Renko Kostja , Seemann Petra , Kornak Uwe , Schomburg Lutz

Selenium (Se) is an essential trace element and is important for maintaining health and preventing disease. Se exhibits its biological function as the 21st proteinogenic amino acid selenocysteine (Sec). Different cis and trans acting factors are necessary for incorporation of Sec into proteins. Se can be transported and stored as Sec in selenoprotein P (SePP), a liver-derived protein which contains up to 10 Sec residues per protein in humans. Thus, SePP functions...

ea0081p31 | Calcium and Bone | ECE2022

Application of Calcium to Phosphorus (Ca/P) ratio in the diagnosis of pseudohypoparathyroidism: Another piece in the puzzle of diagnosis of Ca-P metabolism disorders

De Vincentis Sara , Brigante Giulia , Del Sindaco Giulia , Moretti Antonio , Pagnano Angela , Zirilli Lucia , Rochira Vincenzo , Simoni Manuela , Mantovani Giovanna , Madeo Bruno

Introduction: The serum calcium/phosphorus (Ca/P) ratio has been proposed to identify patients with primary hyperparathyroidism and chronic hypoparathyroidism (HPT) from healthy subjects. However, other disorders of the Ca-P metabolism might present similar biochemical profile of HPT, such as pseudohypoparathyroidism (PHP), for which the use of Ca/P can be useful. Aim: To test the performance of Ca/P ratio in the diagnosis of PHP in comparison to healthy...

ea0015s8biog | Clinical Endocrinology Trust Lecture | SFEBES2008

Clinical Endocrinology Trust Lecture

Connell John

John Connell, MRC Blood Pressure Group, Glasgow, UK AbstractJohn Connell graduated in medicine from Glasgow in 1977. After initial training in endocrinology, he was appointed as a Clinical Scientist to the MRC Blood Pressure Unit, Western infirmary, Glasgow in 1983. He held an MRC Travelling Fellowship in the Howard Florey Institute for Experimental Physiology and Medicine from 1987, working with Professor John Coghlan...

ea0031p218 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

Weight loss after bariatric surgery in women of childbearing age

Alatishe Aderinsola , Ammori Basil J , New John P , Syed Akheel A

Obesity increases the risk of pregnancy-related complications such as miscarriage, foetal abnormalities, hypertension, diabetes, thrombosis, caesarean section and infection. Although bariatric surgery addresses some of these risks, women should defer pregnancy for 12-24 months postoperatively until weight loss has plateaued due to concerns regarding limited maternal weight loss and foetal nutritional deficiency. The aim of this study was to evaluate the impact of pregnancy on ...