Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1263 | Thyroid (non-cancer) | ECE2017

Psychometric evaluation of the newly developed hypoparathyroidism symptom diary

Coles Theresa , Chen Kristina , Nelson Lauren , Harris Nimanee I , Vera-Llonch Montserrat , Martin Susan

Objective: The purpose of this study was to evaluate the psychometric properties of a novel, patient-reported outcome (PRO) measure, the Hypoparathyroidism (HPT) Symptom Diary (HPT-SD), using data collected during a cross-sectional, noninterventional, observational study. The HPT-SD, developed according to the US Food and Drug Administration PRO guidance, addresses the severity of key symptoms (muscle cramping, tingling and muscle spasms/twitching, fatigue, cognition, emotions...

ea0005p151 | Endocrine Tumours and Neoplasia | BES2003

IGF-I inhibits COX-2 function in primary colonic biopsies of patients with acromegaly

Kelly P , Vojnovic I , Fairclough P , Warner T , Bustin S , Jenkins P

Introduction: Cyclooxygenase-2 (COX-2), an inducible enzyme in prostaglandin synthesis, plays a major role in the pathogenesis of sporadic colorectal carcinoma (CRC). COX-2 inhibitors reduce the mortality from sporadic CRC. Acromegaly is associated with an increased risk of CRC, with a preponderance of right sided disease, but COX-2 protein is reduced or absent in acromegalic normal and malignant colonic mucosa. The mechanisms responsible for this are unknown.Aims: (i) To ...

ea0041ep562 | Diabetes therapy | ECE2016

Insulin pump therapy-a different solution for treating diabetes type I

Pejaković Sladana , Tešić Dragan , Stokić Edita , Milankov Andrijana , Prodanović Jovana , Perčić Ivanka , Mitrović Milena , Kovačev-Zavišić Branka

Introduction and aim: Continuous subcutaneous insulin infusion via insulin pump is the most efficient way of imitating physiological insulin secretion, and it also provides better management of diabetes, lower rate of hypoglicemic episodes, better quality of life and prevention of long-term complications of diabetes mellitus. Aim of the research was to determine effects of subcutaneous insulin infusion therapy on parameters of glycoregulation during the two years trial.<p ...

ea0019p197 | Growth and development | SFEBES2009

Altered IGF-I signalling in children born small for gestational age without catch up growth

Butcher I , Whatmore A , Murray P , Westwood M , Clayton P

Background: Infants born small for gestational age (SGA) usually show catch-up growth during the first few years of post-natal life. However, some infants remain small and little is known about the factors governing their growth failure. IGF-I receptor mutations account for a minority of cases therefore we have initiated an assessment of signalling molecules downstream of the receptor.Method: Skin biopsies were obtained with local ethics approval from he...

ea0037oc7.5 | Neuroendocrinology and pituitary-basic | ECE2015

Not so giants: mice lacking both somatostatin and cortistatin have high GH levels, but show no changes in growth rate or IGF-I levels

Luque Raul M , Gahete Manuel D , Pedraza-Arevalo Sergio , Pozo-Salas Ana I , L-Lopez Fernando , de Lecea Luis , Cordoba-Chacon Jose , Castano Justo P

Somatostatin (SST) and cortistatin (CORT) are two highly related neuropeptides involved in the regulation of several endocrine secretions. In particular, SST and CORT are two primary negative regulators of GH secretion. Consequently, SST or CORT knockout (KO) mice exhibit elevated GH levels; however, this does not lead to increased IGF-I levels or somatic growth, which has been suggested that could be due to a compensatory mechanism between both peptides. In order to test this...

ea0019p209 | Growth and development | SFEBES2009

The effect of age on insulin-like growth factor-I and pro-collagen type III N-terminal peptide in elite adolescent athletes and its influence on the detection of growth hormone abuse

Guha N , Erotokritou-Mulligan I , Brigg J , Burford C , Drake T , Strobridge G , Bassett E , Cowan D , Bartlett C , Sonksen P , Holt R

Introduction: Using discriminant analysis, a method based on two growth hormone (GH) dependent markers, insulin-like growth factor-I (IGF-I) and pro-collagen type III N-terminal peptide (P-III-P) has been devised to detect exogenously administered GH. It is believed that GH is a popular substance of abuse amongst adolescent athletes. As previous studies on the detection of GH abuse involved predominantly adult athletes, it is necessary to validate the method in adolescent athl...

ea0025ye1.3 | A successful research career | SFEBES2011

Postdoctoral research – the things I wish I knew

Hanyaloglu Aylin

Many PhD graduates will pursue a postdoctoral training position, most commonly in an academic laboratory. What can you expect from this period in your career? Do you need to go abroad to do a postdoc? What could/should you do to benefit the most of this time? And how can you use your time as a postdoc to help you with your career path once you leave?I recall being very excited about beginning my postdoc and leaving the ‘PhD nest’. I trained and...

ea0020s5.4 | IGF1 survival, proliferation and cancer | ECE2009

IGF-I and neuroprotection

Aleman Ignacio Torres

Neuroprotection defines a set of homeostatic, self-repair mechanisms that probably evolved for the specially demanding conditions imposed by brain function. Among these, intercellular messengers such as the insulin-like growth factors (IGFs), that appeared very early during phylogeny, apparently play a prominent role despite their peripheral origin. In contrast to the heterogeneity seen in primitive organisms where at least 30 different IGF-like peptides are described, in mamm...

ea0016s1.2 | The trick is the combination | ECE2008

The combination of GH/IGF-I makes the difference!

Janssen Joseph

Growth hormone (GH) is the primary regulator of insulin-like growth factor-I (IGF-I) production in a wide variety of tissues. After secretion by the pituitary GH, GH is transported to the liver and stimulates IGF-I production in the liver. The IGF-I produced in the liver accounts for most of the IGF-I in the circulation. The circulating IGF-I will have effects on extra hepatic tissues as the heart, lung, muscles and kidney. Circulating IGF-I feeds back at the level of the pitu...

ea0013s4 | Society for Endocrinology European Medal Lecture | SFEBES2007

GH/IGF-I and the cardiovascular system

Colao Annamaria

Recent epidemiological evidence suggests that low-normal levels of serum IGF-I are associated with increased risk of acute myocardial infarction, ischemic heart disease, coronary and carotid artery atherosclerosis.The IGF-I system is involved in the regulation of cardiovascular physiopathology: it has a physiological role in regulating glucose, protein and lipid metabolism, and in promoting proliferation, differentiation and migration of many cell types....