Endocrine Abstracts

Introduction: Aldosterone (Aldo) decreases the rate of repolarization in rabbit cardiomyocytes and significantly increases the duration of the monophasic action potential in patients with supraventricular arrhythmias, few minutes after its intravenous administration, implying for a non-genomic action. We have previously found a positive linear regression between left ventricular systole duration and plasma Aldo levels in NZW rabbits. To investigate the veracity of the above fi...

Introduction: Thyrotoxicosis has been shown to cause deterioration of glucose levels in patients with DM 2 while return to euthyroidism results in better glycaemic control. Studies in normal subjects suggest that increased thyroid hormones may aggravate insulin resistance and decrease pancreatic secretion of insulin but the exact underlying mechanisms have not been completely elucidated. The purpose of this study was to investigate if this also occurs in subclinical hyperthyro...

Objective: Bleeding is one of the most dangerous complications following thyroid and parathyroid surgery. For this reason prophylactic perioperative thromboprophylaxis is not routinely use. The aim of this study is to investigate the incidence of clinical and subclinical deep vein thrombosis (DVT) and to validate the Caprini score as a predictive factor of high risk patients after these operations.Material and method: This is a prospective study involvin...

Background: Adipose tissue blood flow (ATBF) is important for delivering nutrients and oxygen to adipose tissue (AT), and distributing adipokines and metabolites into the circulation. ATBF has been measured with the 133Xenon wash-out technique (gold standard), microdialysis, laser Doppler Fluximetry, and contrast-enhanced ultrasound. However, due to decline in world-wide 133Xenon production and the invasive nature of other techniques, an alternative metho...

Background: Glucocorticoids have pleiotropic metabolic functions and acute glucocorticoid excess causes dramatic disruption of human metabolism. Whether glucocorticoids exert adipose tissue depot-specific effects on the nontargeted metabolome in unknown.Aim: Assess the nontargeted metabolome in the systemic circulation and in femoral adipose tissue-specific blood samples in response to physiological hyperinsulinaemia and acute hypercortisolaemia.<p c...

Introduction: The familial risks of carcinoids are not clear. There has never been a report of gastrointestinal carcinoid coexisting with horseshoe kidney.Case presentation: We present the case of a 15 mm well differentiated metastatic small bowel NET with vascular and perineural invasion and three of four positive lymph nodes (Ki67: 1.9%, ENETS stage: pT4 pN1 pMX R1) in a 75-year-old British male with episodes of diarrhea and 24 h urinary 5HIAA: 48 (&#6...

Introduction: The relation of hypothyroidism with the breast cancer is described early in the literature based in some common pathophysiological paths which associate thyroid gland and breast tissue.Methods: A literature research in PubMed and Cochrane library database was performed for articles studying any possible association between the risk for development of breast cancer with the presence of hypothyroidism history in women.R...

Background: Cholesterol is a major component of the cell membrane. It plays an important role in its physiology affecting vital properties, such as membrane fluidity, cation transport, cell receptors, osmotic resistance etc. Abnormal conditions that change serum cholesterol concentration (SC) can also alter erythrocyte membrane cholesterol concentration (EMCC) possibly resulting in differentiation of several membrane functions.Aim: To investigate whether...

Background – objective: Medullary thyroid carcinoma and hyperparathyroidism coexistence is well described in the literature. On the other hand, data regarding the coexistence of non-medullary thyroid cancer and hyperparathyroidism are scarce. The aim of this study was to evaluate the occurrence of such coexistence.Methods: This is a retrospective study of all patients with primary or secondary hyperparathyroidism who underwent parathyroidectomy in o...

Background: The majority of complications in transfusion dependent thallasemic and with sickle cell anemia patients are due to iron overload. This is responsible for the beginning of haemosiderosis, clinical symptoms and dysfunction of important systems, specially after the 2nd decade of life. The increase of the iron accumulation is caused by hemolysis, high iron absorbance and mainly by transfusion treatment. The appearance of diabetes mellitus depends on the significance an...