Endocrine Abstracts

Pregnancy is associated with changes in both size and function of the pituitary gland. Thus diagnosing pituitary dysfunction during pregnancy can be challenging. For women with a pre-existing adenoma, there is limited evidence regarding safety in pregnancy for medical therapies used to control hormonal excess. Management includes optimisation of hormonal function and close monitoring for signs of tumour progression. Most women can be managed conservati...

Rates of among women of reproductive age are rising such that 1 in 5 women in the UK are obese at antenatal booking. Female obesity is associated with reduced fertility including ovulatory dysfunction and increased time to pregnancy. Obese pregnancy is associated with increased pregnancy loss and stillbirth, and with increased risk of major pregnancy complications including gestational diabetes and preeclampsia. In addition there are short and long-term complications for the o...

Since completing a PhD in Developmental Neurobiology at King’s College London, I have worked as a Grants Adviser at the Wellcome Trust. Not-for-profit organisations like the Wellcome Trust hold a diverse range of career opportunities for scientists with PhD and post-doctoral experience, from communications to research management. In this short overview talk I’ll give an insight into the role of the Grants Adviser, the opportunities for scientists in the charitable se...

Rates of among women of reproductive age are rising such that 1 in 5 women in the UK are obese at antenatal booking. Female obesity is associated with reduced fertility including ovulatory dysfunction and increased time to pregnancy. Obese pregnancy is associated with increased pregnancy loss and stillbirth, and with increased risk of major pregnancy complications including gestational diabetes and preeclampsia. In addition there are short and long-term complications for the o...

Since completing a PhD in Developmental Neurobiology at King’s College London, I have worked as a Grants Adviser at the Wellcome Trust. Not-for-profit organisations like the Wellcome Trust hold a diverse range of career opportunities for scientists with PhD and post-doctoral experience, from communications to research management. In this short overview talk I’ll give an insight into the role of the Grants Adviser, the opportunities for scientists in the charitable se...

Primary hyperparathyroidism in pregnancy is rare, with a reported incidence of 1%. It is often asymptomatic with the majority of cases in case-series identified incidentally. Published case series report dramatic maternal complications including nephrolithiasis, pancreatitis, hyperemesis gravidarum, pre-eclampsia and hypercalcaemic crises with fetal complications including intrauterine growth restriction, preterm delivery and neonatal hypocalcaemic tetany. Severity of complica...

With over 650 million people obese in 2016 and 2.8 million people dying a year from being overweight or obese, the obesity epidemic is now linked to more deaths worldwide than being underweight. This high mortality rate and disease burden are potentially preventable if risk factors such as unhealthy diet and physical inactivity were eliminated. The classification of obesity is defined as a Body Mass Index (BMI) equal to or above 30 kg/m2. Weight management services ...

One in five women in the UK is obese (BMI >30 kg/m2) at antenatal booking. Maternal obesity is associated with complications for the mother including increased risk of developing gestational diabetes, pre-eclampsia and need for caesarean section. For the offspring short term complications include risk of macrosomia and need for admission to the neonatal unit. It is now apparent that the effects of maternal obesity for the offspring extend beyond the neonatal per...

Case report: A 41-year-old lady, previously diagnosed with Graves’ disease, had been treated with 12 months carbimazole in a standard block and replace regimen. The hyperthyroidism relapsed following treatment withdrawal so she was treated definitively with radio-iodine therapy, remaining well for 5 years, without hypothyroidism. The patient commenced the lighter life diet due to weight gain and subsequently presented with weight loss of a stone and atrial fibrillation (A...

This gentleman originally presented at the age of 60 years old with slurred speech, confusion and cerebellar signs and was found to have raised calcium and PTH. His sisters, son and daughter were known to have hyperparathyroid-jaw tumour syndrome (HPT-JT) due to a novel germline Leu63Pro missense mutation in CDC73 exon 2. An MRI brain identified cerebellar lesions and he had positive voltage gated potassium channels; both of indeterminate aetiology follo...