Endocrine Abstracts

Background: Persistent/recurrent disease in the neck is frequent in patients with papillary thyroid cancer. The main goal of this study was to evaluate the efficacy of the reoperation and radioiodine (RAI) treatment for persistent/recurrent disease after the initial treatment. Patients and Methods: A total of 30 patients (13 M/17 F) with papillary thyroid cancer were enrolled in this study. Seven cases (23.3%) had an aggressive subtype of papillary carcinoma. All had been subm...

Objectives: Overall, papillary and follicular carcinoma is associated with a 30-year cancer-related death rate of 6 and 15%, respectively. Poorer outcomes have been associated with older age, male gender, tumor size, grade and extrathyroidal extension. We investigated the clinical and laboratory characteristics of 40 patients who presented recurrence of thyroid disease.Patients data: • 40 Patients (21 Females and 19 males) with papillary thyroid can...

Introduction: 21-hydroxylase deficiency (21-OHD) is a common inherited disorder accounting for 90–95% of congenital adrenal hyperplasia (CAH) cases. Some cases may be diagnosed in adulthood after the incidental discovery of adrenal masses on computerized tomography (CT).Case report: A 59-year-old male was investigated for incidentally discovered bilateral adrenal masses in an abdomen CT scan, measuring 5 cm on the right and 8 cm on the left adrenal....

Introduction: Vitamin D concentrations during pregnancy are measured to diagnose states of insufficiency or deficiency. The aim of this study is to apply accurate assays of vitamin D forms (single hydroxylated (25(OH)D2, 25(OH)D3), double-hydroxylated (1α,25(OH)2D2, 1α,25(OH)2D3), epimers (3-epi-25(OH)D2, 3-epi-25(OH)D3)) in mothers (serum) and neonates (umbilical cord) i) to expl...

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....

Background: The renin-angiotensin system is important for blood pressure control. Screening and diagnostic tests used so far to diagnose patients with aldosterone related hypertension does not take into consideration the stimulating ACTH effect on aldosterone secretion.Objective: To assess the role of aldosterone in essential hypertension using a modified suppression test, performed under suppressed ACTH levels.Subjects and methods...

IntroductionPrimary hyperparathyroidism (PHPT) is characterized by excessive secretion of parathyroid hormone (PTH) from one or more parathyroid glands. PTH has a central role in the regulation of calcium and phosphate and the classic disorder causes primarily hypercalcemia associated with renal and bone manifestations. Non-classical symptoms are also present including cardiovascular, gastrointestinal, psychiatric, neuro-cognitive disorders. Regarding ca...

Introduction: Primary adrenal insufficiency (PAI) can be of autoimmune origin (AI), non-autoimmune origin (bilateral adrenalectomy, acute hemorrhage, infection) (NAI) or pharmaceutical (mitotane) origin. Studies have shown that these patients develop long-term morbidities and increased mortality due to excessive glucocorticoid tissue exposure. Data about differences concerning hydrocortisone (HC) needs, cortisol hormonal levels and metabolic parameters in these patients are sc...

Objectives: Osteogenesis imperfecta (OI) is a group of genetic disorders that mainly affects the bones. The underlying mechanism is usually a disorder of connective tissue due to lack of type I collagen. Usually, the disease is due to mutations in the COL1A1 or COL1A2 genes. The disease is inherited in an autosomal dominant manner or occurs via a de novo mutation. There are eight types of the disease. Type I is the most common and the least sever type and is due to mutation in...

Background: Many patients with differentiated thyroid cancer (DTC) are treated with radiodine (I-131) after thyroidectomy, while they are hypothyroid and all are submitted to withdrawal of LT4 periodically for the evaluation of their disease. Among the tests used for follow-up is serum thyroglobulin (Tg) as a tumor marker, and occasionally, total body scan with I-131. Maximal sensitivity of the aforementioned tests is established in the hypothyroid state, under elevated thyrot...