Endocrine Abstracts

Differentiated thyroid carcinoma is the most common endocrine malignant tumor. Papillary carcinoma frequency in our country is 80% of thyroid neoplasia. Papillary thyroid carcinoma usually metastasizes to cervical lymph. Metastases to distant organs are rare and most often affect the lungs, liver and bones. Despite of its anatomical proximity, metastasis parotid have not been described in the existing papillary carcinomas literature. We report a case of parotid gland metastasi...

Objective: Transition from pediatric to adult health care is a particularly vulnerable period for patients with inborn metabolic diseases.Our objective in this study was to evaluate the current transition of patients with phenylketonuria (PKU) in Malaga, Spain, by analysis of the metabolic control, medical care, patients satisfaction and phychosocial status.Material and methods: We evaluate all the patients transferred to our adult...

Introduction: The gold standard for evaluating Occult Parathyroid Adenomas (OPa) in patients with biochemical pattern of primary hyperparathyroidism (PHPT) is the 99mTc-MIBI parathyroid scan. 18F-Fluorocholine (18F-FCH) PET/CT has been proposed as a potential technique for detection and localization of OPa when 99mTc-MIBI scan is negative or inconclusive.Aims: To evaluate sensitivity and positive predictive value of 18F-Fluorocholine PET/CT in patients w...

Objective: The purpose of this study was to evaluate the psychometric properties of a novel, patient-reported outcome (PRO) measure, the Hypoparathyroidism (HPT) Symptom Diary (HPT-SD), using data collected during a cross-sectional, noninterventional, observational study. The HPT-SD, developed according to the US Food and Drug Administration PRO guidance, addresses the severity of key symptoms (muscle cramping, tingling and muscle spasms/twitching, fatigue, cognition, emotions...

Aim: To analyze the influence of bariatric surgery over serum lipids in patients with morbid obesity after 1 year of surgery.Methods: Retrospective study of 88 patients before and after 1 year of bariatric surgery (65 by pass and 23 sleeve). We collected data about age, sex, other diseases, anthropometric measures and biochemical parameters: glucose, uric acid, total cholesterol (TC), HDL-C, LDL-C, triglycerides (TG), VLDL and non-HDL-C, homocistein and ...

Rationale: Patients with morbid obesity may have vitamin D deficiency and bariatric surgery may exacerbate it due to various factors such as lack of dietary compliance, reduced intake, malabsorption, etc.Objective: To study the prevalence of vitamin D deficiency in patients with morbid obesity before and after bariatric surgery and its relationship with other laboratory parameters.Methods: A retrospective study of 72 morbidly obese...

The RET/GFRa/GDNF system displays a wide distribution in tissues such as nervous system, kidneys, intestine or testis. RET has been implicated in human pathologies. RET is a tyrosine-kinase receptor activated by four ligands GDNF, NTN, ART and PSPN through four co-receptors GFRa1, 2, 3 and 4 respectively. Activation of the receptor leads to cell differentiation or proliferation. Our group has shown that RET is expressed specifically in the somatotrope (GH) adult cell populatio...

Background: Cardiovascular disease (CVD) is the leading cause of death in persons with type 1 diabetes (T1DM). However, there are no CVD-risk prediction models for this population in widespread use and those developed from general population and type 2 diabetes have been shown to underestimate CVD-risk in T1DM. Recently, the Steno Type 1 Risk Engine (ST1RE) was developed for predicting CVD in a cohort of T1DM persons without clinical CVD. We investigate the relationship betwee...

Chronic hypoparathyroidism (HypoPT) is a rare disease associated with a variety of symptoms and diminished health-related quality of life (HRQoL). This study aimed to characterise and quantify the symptom burden, HRQoL, and overall disease impact in patients receiving recombinant human parathyroid hormone (rhPTH1-84, Natpar®) for inadequately controlled HypoPT and in symptomatic patients receiving standard therapy (ST; calcium and/or vitamin D supplements). A w...

Total vitamin D levels are decreased in obese patients probably due to an increased volume of distribution mechanism. Recently introduced direct assays allow the measurement of free-vitaminD3 levels (fvitD3). Few data are available regarding fvitD3 levels in obese people and the effect of bariatric surgery upon its circulating concentration. We aimed to evaluate fvitD3 in a cohort of obese patients before and after bariatric surgery treatment and its relationship to phosphocal...