Endocrine Abstracts

Introduction: Multi Nodular Goitre(MNG) has a slow, progressive growth. An apparently asymptomatic MNG can already have caused retrosternal upper airway obstruction. Yet MNG can also cause compressive manifestations without retrosternal extension. Timing of surgery can be critical for patients with a large goitre. The evidence is poor to guide management of large MNG with absolute indications for surgery. The aim of this uni-centre study is to analyze patients with large MNG a...

In pregnant women with thyroid diseases an increased amount of LT4 may be required for the correction of hypothyroidism or treatment of nodular goiter. Aim of this study was to assess the amount of the variations of LT4 requirement in pregnant women with thyroid diseases. To address this issue, we retrospectively evaluated a cohort of 107 women treated with LT4 divided in two groups: 42 euthyroid (E) (affected by nodular goiter (NG) treated with LT4 suppressive therapy) and 65...

Background: Mitotane antitumor efficacy is related to plasma levels. Objective responses have been associated with mitotane plasma levels >14 mg/l. However, high plasma levels >20 or >30 mg/l are at higher risk of toxicity, especially neurotoxicity. National-based survey is lacking to evaluate the frequency and severity of high mitotane plasma levels. Our aim was to retrospectively describe serious adverse events (SAE).Methods: Mitotane plasm...

CDGP is a common growth disorder, often dominantly inherited. Genetic association is thus very likely. There are many possible candidates but none are yet linked to CDGP. We assessed the possible contribution of L, LR genes (mutations in each cause very delayed or absent puberty), CART (mediates the effect of L on GnRH pulse generation), and GPR54 (a hypothalamic G-protein coupled receptor, which is mutated in familial hypogonadotrophic hypogonadism) genes.<p class="abstex...

High protein diets suppress appetite and facilitate weight loss, but are difficult to adhere to. Understanding the mechanisms by which protein suppresses appetite may establish targets for more acceptable interventions to treat or prevent obesity. Of particular interest is the concept of functional foods or novel products, which aim to potentiate satiety.Receptor systems that respond to amino acids have been identified. However, the specific mechanisms r...

The importance of the sRANK-L / RANK / Osteoprotegerin (OPG) system in osteoclast function has clearly been demonstrated in the rat. Activating and inactivating mutations lead to severe disturbances of bone remodelling.Since this early animal work, there have been several studies designed to assess the importance of sRANK-L / RANK / OPG in diseases of the human skeleton. sRANK-L and OPG are measurable in blood.This cross-sectional ...

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...

Lactate is a metabolite that activates the G-protein coupled receptor, Hydroxycarboxylic acid Receptor 1 (HCAR1) to regulate physiological processes such as lipolysis, cancer cell survival, and neuroprotection. Lactate exists in two forms, L+ and D-, with the L isoform predominant in the human body. Interestingly, both isoforms are only found together in the gastrointestinal tract. L-lactate is synthesised as a by-product of anaerobic respiration, whereas D-lactate, is a produ...

In pregnant women with a thyroid disease an increased amount of LT4 may be required for the correction of hypothyroidism or treatment of nodular goiter.Aim of this study was to assess the amount of the variations of LT4 requirement in pregnant women with thyroid diseases.To address this issue, we retrospectively evaluated a cohort of 138 women treated with LT4 divided in two groups: 47 euthyroid (E) (affected by nodular goiter (NG)...

Background and aim: Subclinical hypothyrodism (SH) appears to be associated with mood and changes. The aims of this study were: i) to determine whether depression is more common in SH, and ii) to investigate the effects of L-thyroxine (LT4) therapy on depressive symptoms.Methods: 31 patients with SH and 36 age amd BMI matched healthy controls were included. Beck and Hamilton scales were used to evaluate depression...