Endocrine Abstracts

Introduction: Natural history of lung neuroendocrine tumours (NETs) and in particular of two histological subtypes, atypical carcinoid (AC) and large cell neuroendocrine carcinoma (LCNEC), is poorly known.Aim of the study was to determine disease-free survival (DFS) and overall survival (OS) of sporadic, resectable, non-metastatic lung AC and LNEC.Patients and methods: This retrospective study involved 116 consecutive patients surg...

Gonadotroph tumours (GoTs) are frequent intracranial neoplasms that represent 30% of all pituitary tumours (PiTs). While GoTs are responsible of an important morbidity, their tumorigenesis is not yet understood, and their treatment is limited to surgical resection and radiotherapy. The absence of identified driver-genes combined with their heterogeneity and silent behaviour (i.e. lack of hormone hypersecretion) limit the development of medical treatment. The current lack of re...

Individuals with Turner syndrome (TS) have an increased risk for congenital and acquired cardiovascular disease (23–50%). This results in increased morbidity and mortality throughout the TS lifespan. There is an increased prevalence of bicuspid aortic valve malformation, coarctatio of the aorta, elongation of the transverse aortic arch, and partial anomalous venous return. In addition, TS females may develop aortopathy that may result in clinically significant aortic dila...

Despite intense efforts over the past decades, human pancreatic beta cell lines with physiological insulin secretion have not been available. We have developed a robust transplantation model of fetal human pancreases that recapitulates pancreas development and combined such model with integrative lentiviral-mediated gene transfer. This resulted in production of human transgenic pancreases in which dynamic aspects of development can be studied. We thus forced expression of immo...

Transition from pediatric to adult care is a challenging turning point for patients, physicians and health care system that need to be planned and adapted to each center. Endocrine conditions present some specific concerns at transition that need to be clarified to insure optimal care during adulthood. We had the opportunity to set up a network to evaluate transition process of patient with a chronic endocrine condition at the Department of Endocrinology and Reproductive Medic...

Recent large twin studies have definitively shown that more than 70% of the variance of the BMI and waist is genetically determined in both adults and children, suggesting that the epidemics of obesity and subsequent T2D are mainly due to the environmental pressure targeting individuals who are particularly vulnerable to metabolic diseases. The dissection of monogenic early onset severe obesity and T2D cases have identified a variety of causative genes that are involved in two...

The pharmaceutical armamentarium available for contraception is remarkable and extraordinary progress has been achieved since 1960, when the first hormonal contraceptive, Enovid, was approved in the USA. However, the demand for new methods, for improvement of existing methods, and easier availability, remains extraordinary. Indeed, the number of unintended pregnancies is still too high, averaging 40% of all pregnancies. In addition, 50% of these pregnancies are followed by abo...

Growth hormone (GH) and insulin-like growth factor-I (IGF-I) have important metabolic actions. GH/IGF-I excess and GH deficiency are each associated with ‘opposing’ comorbidities that often mirror one another. Cardiac and vascular comorbidity demonstrates that ‘too much’ may be as bad as ‘too little’. An association between acromegaly and increased cardiac mortality has long been claimed. This was based on epidemiological studies of patients treat...

50 years after the approval in the USA of the first oral contraceptive, it is quite remarkable that this considerable medical advance, may be the greatest medical discovery in the last century, the combined pill, which replaced condoms and unreliable natural methods, is still a matter of controversy. Recently, fear for hormones is more and more common in women in relation with the pill scares observed in UK and in France, and in relation with the media noise on Endocrine disru...

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