Endocrine Abstracts

Introduction: To the best of our knowledge, there is no case report of Evans’ syndrome associated with TSH secreting pituitary adenoma (TSHoma).Case report: A 30-year-old woman was admitted to near hospital due to purpura and ecchymoses on her limb and body and epistaxis. A hematologic disease was suspected and she was referred to our hospital. The diagnosis of Evans’ syndrome was made on the bases of idiopathic thrombocytopenic purpura (ITP) a...

Ronald M Evans, The Salk Institute for Biological Studies, LaJolla, California, USA Abstracthttp://www.endocrine-abstracts.org/ea/0031/ea0031pl1biog.htm...

Nuclear hormone receptors (NHRs) are a large family of ligand-activated transcription factors that regulate programs of cellular growth, differentiation and homeostasis. The structurally conserved ligand binding domains (LBDs) of NHRs bind to hydrophobic small molecules including steroid hormones, fat soluble vitamins and bile acids, thereby interpreting small molecule cues to affect transcriptional readouts.The temporal correspondence between metabolic ...

It has been noted that there are differences in the hypothalamic-pituitary-adrenal (HPA) axis between the sexes, as well as changes in the axis with age. The differences in the HPA axis between the gender and age groups are thought to be due to differences in the efficiency of glucocorticoid (GC) negative feedback. The pituitary, a principle site of GC negative feedback, is the focus of this investigation. Annexin-1 (ANXA1) is a member of the annexin family of phospholipid- an...

Dr. Ronald M Evans is known for his discoveries and characterization of nuclear hormone receptors, the establishment of the nuclear receptor super family and the elucidation of their universal mechanism of action, this revealed how receptor activation by lipophilic hormones and drugs are transformed into physiology and the treatment of disease.Dr R M Evans obtained his BA and PhD from the University of California, Los Angeles, School of Medicine in 1970 ...

Abstract for Society for Endocrinology Conference 2003Category: Clinical case report (Young Endocrinologist)AbstractTitle: A CASE OF HYPERTHYROIDISM PRESENTING AS HAEMATOLOGICAL MALIGNANCYAuthors: K.M. Evans, D.E. Flanagan; Dept. of Endocrinology and Diabetes, Derriford Hospital, Plymouth, PL6 8DHA 30 yr old man was referred to the Haematology department with axil...

Current cortisol dosing regimes for patients with adrenal insufficiency are unable to accurately replicate the physiological profile of healthy patients. This work is part of an interdisciplinary study with the aim of using mathematical approaches to understand the treatment strategies for patients with adrenal insufficiency. We also aim to then tailor treatments specific to an individual or situation. We present a simplified model of hydrocortisone delivery via intravenous bo...

Feeding a cafeteria diet in rodent pregnancy can induce altered food preferences and greater weight gain in the resulting offspring. The aim of this study was to examine the effect of diet induced obesity or high fat feeding on maternal adaptation to pregnancy.Three week-old Wistar rats were fed either chow diet alone (n=24) or cafeteria diet (n=24) for 8 weeks before mating. After mating, the rats were maintained on the chow diet (CO/CF) (...

It has previously been shown that protein restriction during pregnancy impairs the physiological adaption to pregnancy by reducing plasma volume expansion. This may mediate the effects of maternal diet on placental and fetal development. This study investigated the mechanisms by which maternal diet interacts with plasma volume expansion.Female Wistar rats were mated and fed a control (18%, n=32) or low protein (9%, n=32) diet during pregnan...

Dr David Unwin MbChB FRCGP Our GP practice of 9500 people has suffered an eight-fold increase in the number of patients with T2D since 1986. In addition, those affected now develop this condition decades earlier than was the norm back in 1986. A situation replicated all over the developed world. Nationally there are 122,780 children and young adults under the age of 40 years with type 2 diabetes, 1,560 (around 1.3 per cent) are under the age of 19 years. In 2013 our practice d...