Endocrine Abstracts

Background: TIRADS scoring is used to assess the thyroid nodules using USG, commonest used is ACR-TIRADS; another is K-TIRADS scoring. Nodule stiffness is assessed by elastography strain Rago scoring & FNA nodule gives lower (benign) or higher Bethesda (possible malignant) category report. The combined use of TIRADS & Rago scorings with Bethesda as final output can assess whether addition of elastography improves the correlation between thyroid nodule TIRADS scoring an...

Background: Rapid improvements in imaging have led to a 10-fold increase in the incidence of adrenal incidentalomas (AIs) over the past two decades. Delays in the diagnostic evaluation of AIs are associated with patient anxiety and significant burden on medical resources. We retrospectively audited the investigation and management of AIs at Guy’s and St Thomas’s NHS Foundation Trust (GSTT).Methods: Patients wit...

Dr David Unwin MbChB FRCGP Our GP practice of 9500 people has suffered an eight-fold increase in the number of patients with T2D since 1986. In addition, those affected now develop this condition decades earlier than was the norm back in 1986. A situation replicated all over the developed world. Nationally there are 122,780 children and young adults under the age of 40 years with type 2 diabetes, 1,560 (around 1.3 per cent) are under the age of 19 years. In 2013 our practice d...

A 79-year-old lady presented with a 6 months history of confusion and slurred speech and was found to have recurrent spontaneous hypoglycaemia (plasma glucose 1.3, 1.8 and 2.6 mmol/l). Pituitary and adrenal function were normal, and raised insulin (102 pmol/l) and C-peptide (630 pmol/l) levels confirmed the diagnosis of insulinoma, which was identified as a solitary 2 cm mass in the head of pancreas. Treatment with diazoxide 100–150 mg tds led to normalisation of g...

Professor David RayDavid Ray graduated in Medicine from University of Manchester in 1987. He trained in medicine and endocrinology in the North West, before doing a PhD with Anne White and Julian Davis, again in Manchester. Towards the end of his PhD he was offered a post with Shlomo Melmed at UCLA, and, attracted by the lab, and the adjacent coast, headed west. This research post stimulated an ...

Background: Hypercalcaemia is common in renal transplant recipients, the majority of whom have PTH-dependent hypercalcaemia due to tertiary hyperparathyroidism. PTH-independent hypercalcaemia is less common and is associated with significant, treatable underlying pathologies. In this study, we aimed to evaluate the prevalence and aetiology of PTH-independent hypercalcaemia in post-renal transplant patients.Method: This was a retrospective, single-centre ...

We present the case of a woman who first presented at age 18 with hirsutism. Menarche had been normal and she had regular menses. She gave no past medical history except that at age 6 she had been admitted to hospital with tonsillitis that was complicated by diarrhoea and vomiting, drowsiness and hypotension. At that time, Na+ was 130 mmol/l and K+5.8 mmol/l. She was treated with antibiotics and fluids and improved; electrolytes returned to normal.<p ...

3-Iodothyronamine (T1AM) is a novel endogenous derivative of thyroid hormone (TH), recently described by Scanlan et al. (Nat. Med. 10: 638, 2004). In vitro, T1AM can stimulate the production of cAMP via activation of a heterologously expressed G protein-coupled receptor (GPCR) now referred to as trace amine-associated receptor 1 (TAAR1; Lindemann et al. Genomics 85: 372, 2005). In adult, unanesthetized C57Bl6/J mice, T1AM produces prof...

Background: Diagnosis of adrenal hypofunction requires a high index of suspicion. A frequent cause is iatrogenic glucocorticosteroid prescribing hence the need for a clinical review after a prolonged course.Aim: A review of glucocorticosteroid prescribing and auditing SST outcomes in a large private hospital.Methods: Electronic records over an 18 month period were analysed for SST results, patient demogra...

Background: Diagnosis of adrenal hypofunction requires a high index of suspicion. A frequent cause is iatrogenic glucocorticosteroid prescribing hence the need for a clinical review after a prolonged course.Aim: A review of glucocorticosteroid prescribing and auditing SST outcomes in a large private hospital.Methods: Electronic records over an 18 month period were analysed for SST results, patient demogra...