Endocrine Abstracts

Background: Bullous pemphigoid is an autoimmune blistering disease that commonly arise in elderly with increased risk for mortality and morbidity. The aetiology of this disease is not entirely clear, although a few cases have been described with dipeptidyl peptidase IV inhibitors.Case 1: A 81-year-old man presented with bullous pemphigoid after 28-month treatment with repaglinide, vildagliptin, and metformin. The patient’s condition didn’t impr...

Objective: Stress causes negative effects at all the body especially the heart. As a result of the damage of secreting various hormones which stress cause to secrete in the body. During the stress, respiration, tension, heart speed and catecholamine level increase. All these can be considered as a risk factor for the heart disease. In our study, we aimed to examine stress’ possible histopathological changes on heart muscle.Methods: Eight adult femal...

Objective: Stress, which is seen prevalently among people, causes a general situation of tension via damaging the balance of the body. During stress, it is known that, at the first, central systems, like nerve system, heart and blood circulation system, nutritive system, genital systems and adrenalin tissues are also affected. In this study, kidney was histopathologically examined on the rat model in order to investigate how and in what level the kidneys are affected from the ...

Objective: Placental lactogen (PL) produced by the placenta stimulates lipolysis and fatty acid metabolism in the mother. PL is an anti-insulin hormon. It adjusts the metabolic state of the mother during pregnancy to make easy the energy supply of the fetus. It also reduces maternal tissue sensitivity to insulin, leading to gestational diabetes. A moderate hypertriglyceridaemia due to uncontrolled diabetes may be noticeably worsen by the gestation. As a result, acute hypertrig...

Objective: Unexplained infertility is 15% among all infertility cases. Many forms of stress, including psychological and physical can effect male fertility and reproductive activity. In this study, we aimed to investigate possible histopathological effects of physical and psychological stress on rat testis at light microscopic level.Methods: Eight adult, male Sprague Dawley rats were used in this study. Rats were randomly divided as control (n=4) ...

We report a patient with mycosis fungoides treated with bexarotene (Targretin), a synthetic retinoid analog with specific affinity for retinoid X receptor. This patient developed hypopituitarism characterized by hypogonadism, hypothyroidism, and hypoadrenalism. Although central hypothyroidism is a common side effect of bexarotene, central hypogonadism, and hypoadrenalism has been reported in one case. Clinicians should have high index of suspicion for hypopituitarism in patien...

Background and aims: The type 1 DM patients who are GAD antibody positive have more risk of autoimmune thyroid disease than who are negative. In patients with autoimmune thyroid disease there is a significantly increased risk of anti-pancreatic autoimmune response as shown by increased GAD antibody positivity compared to normal population. However, the linkage between IA2 and thyroid autoimmunity is evaluated in one studied. Our aim is to evaluate the frequency of presence of ...

Objective: Stress has been linked to several diseases. In the course of stress; blood sugar. cortisol and catecholamine levels increase. Visceral hypersensitivity will increase due to catecholaminergic discharges leading to an over-induction of the intrapancreatic secretion. A chronically stress has a role in the induction of insulin resistance in different tissues and pancreas begins to release excessive insulin causing burned out pancreas. For this reason, it becomes insulin...

Introduction: Although pericardial effusion is a common finding in primary hypothyroidism, massive pericardial effusion or pericardial tamponade are rare. Herein, we describe a newly diagnosed case of primary hypothyroidism initially presenting with massive pericardial effusion.Case report: A 64 years old male patient attended to the emergency unit with worsening dyspnea over the past 1 month. ECG showed a low voltage QRS wave. Chest X-ray showed increas...

Introduction: Klinefelter syndrome (KS) is the most common chromosomal disorder characterized by clinical features of hypogonadism and infertility. Portal vein aneurysms are very rare clinic findings. Reported cases are increasing due to use of modern imaging techniques in clinic practise.Case report: 19-year-old man was admitted to our hospital with complaints of abdominal pain, nausea, and vomiting associated with eating. He was recently diagnosed with...