Endocrine Abstracts

Introduction: We have generated a truncated Growth Hormone Receptor (GHR) fused to the cell membrane by a glycosyl phosphatidylinositol anchor (GHR-GPI). The protein consists of the complete extracellular domain of the GHR, but lacks the intracellular domain, and we predict it would act as a GH antagonist. Aim: To test if partially-purified soluble GHR-GPI could re-insert into CHO cell membranes. Material and methods: Membrane preparations were made from CHO cells stably expre...

Background: Metabolic syndrome has been introduced to increase the incidence of cardiovascular diseases and type 2 diabetes mellitus. Our aim of this study was to investigate the relation for normal fasting plasma glucose levels and metabolic syndrome in normoglycemic adults.Methods: The study subjects consisted of 636 individuals who visited the Center for Health Promotion in Pusan National University Hospital for a medical checkup in 2002 to 2005. Amon...

A 63-year old woman presented with a 3 weeks history of sweating, panic attacks and vomiting. Urine dipstick on admission was positive for glucose (3+) and ketones (2+) and lab glucose was elevated at 26 mmol/l. Based on the findings she was treated as diabetic ketoacidosis and commenced on insulin. Further investigations showed an elevated urinary catecholamines and marked hypercalcaemia (adjusted calcium 3.10 mmol/l) with unsuppressed PTH at 71 pg/ml (normal 12–72 pg/ml...

Telmisartan, an angiotensin II type 1 receptor blocker (ARB), is widely prescribed for the treatment of hypertensive patients with simultaneous diabetes mellitus (DM). Unlike other ARBs, telmisartan is reported to have various ancillary effects as well as common blood pressure-lowering effect. In this regard, telmisartan improves endothelial dysfunction and cardiovascular complications in DM patients and is recently reported to reduce new-onset DM incidence. However, effects a...

Synthetic pyrethroids (SPs) are the most common pesticides which are recently used for indoor pest control. The widespread use of SPs has resulted in the increased exposure to wild animals and humans. Recently, some SPs are suspected as endocrine disrupting chemicals (EDCs) and have been assessed for their potential oestrogenicity by adopting various analyzing assays. In this study, we examined the estrogenic effects of λ-cyhalothrin (LCT) and cypermethrin (CP), the most ...

Backgrounds: As the average lifespan in human increases, osteoporosis and osteoporosis-related fractures have been major health care problems. Despite recent advances in medical treatment, few studies have assessed the recognition of osteoporosis by general adults. This study examined the recognition of osteoporsosis and analysed the relating factors.Methods: We made one to one questions in a rural area called chunjunlee in chunchon city. The questionnai...

Background: Polycystic ovary syndrome (PCOS) is common with a suggested prevalence of 6–7% in Caucasian women of reproductive age. The presence of cardiovascular risk factors of obesity, insulin resistance and dyslipidaemia may predispose women with PCOS to coronary heart disease, although this remains controversial. This study aimed to contrast and compare the changes in lipid profile and hs-CRP following treatment with metformin, orlistat and pioglitazone in women with ...

Waterhouse–Friderichsen Syndrome is adrenal gland failure due to adrenal haemorrhage. It is an uncommon but usually life-threatening condition, which can be one of the serious complications of severe sepsis. Clinical manifestations of adrenal haemorrhage can vary widely depending on the degree and rate of haemorrhage. Adrenal haemorrhage may result from trauma, sepsis, anticoagulation medication, coagulopathy, autoimmune conditions, underlying tumour or idiopathic disease...

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...

Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases. Glycogen synthase kinase 3β (GSK3β) is reported to mediate TNFα-stimulated nuclear factor-κB (NF-κB) activation and expression of vascular adhesion molecules. Although a few clinical trials have suggested that telmisartan, an a...