Endocrine Abstracts

Background: We would like to present a case of pancreatic encephalopathy induced by DKA induced hypertriglyceridemia. The triad of acute pancreatitis, hypertriglyceridemia and diabetes is a rare occurrence. Through our case we aim to highlight the importance of making an early diagnosis as a delay in diagnosis can worsen outcomes.Case history: We present the case of a 51 year old Type 2 Diabetic non compliant with her medications who was admitted to the ...

Developments in next-generation sequencing technology have revolutionised the landscape of genetic testing for heterogeneous genetic disorders. There is an emerging need for closer cooperation between endocrinologists and clinical geneticists, including the setting up of multidisciplinary clinics. Examples from a range of endocrine disorders and syndromes diagnosed by targeted single gene testing, multigene panel tests and whole exome/genome sequencing techniques will be prese...

Background: Peri-operative glucocorticoids are routinely administered to patients undergoing trans-sphenoidal surgery for non-functional pituitary adenomas (NFPA) irrespective of the integrity of hypothalamic-pituitary-adrenal (HPA) axis.Aim: To evaluate HPA axis before and three months after endoscopic trans-sphenoidal adenomectomy (E-TSA) in patients with clinically NFPA utilizing 1 mg ACTH stimulation test and determine the need for glucocorticoid adm...

Pseudohypoparathyroidism type 1b (PHPT1b) is a rare disorder due to resistance to parathyroid hormone (PTH) and subsequent hypocalcaemia, hyperphosphataemia and normal or raised PTH levels. Sufferers usually present in childhood with seizures or tetany due to hypocalcaemia. Typically, PHPT1b is associated with defects on the long-arm of chromosome 20 in the form of uniparental (paternal) disomy of 20q or genetic mutations or sporadic epigenetic changes in GNAS gene. G...

The European Academy of Andrology (EAA) recently published consensus guidelines aiming to standardize the care provided to patients with Klinefelter syndrome (KS) across different stages of development. In this retrospective cross-sectional study, we reviewed the clinical care provided to 76 KS patients at Nottingham University Hospitals between 2000 and 2020.Methods: Data regarding age at presentation (n=30 paediatric, adult 46...

Background: Neuroendocrine tumor (NET) metastases to the heart are found in 1-4% of NET patients and have been reported primarily in the form of individual cases. We investigated the incidence, clinical characteristics, imaging features, and outcomes of NET patients with cardiac metastases on 68Ga-DOTATATE PET/CT.Methods: The medical records of 406 neuroendocrine tumor patients who underwent 68Ga-DOTATATE PET/CT for their clinical c...

Gonadotroph pituitary adenomas are common but majority of them are classified as non-functional as they do not lead to features of hormonal excess. Functional gonadotroph adenomas are rare and there are only few small series or individual case reports about these.Case report: 45-year-old gentleman presented with headaches, progressive visual failure and complaint of excessive tiredness. He had normal libido and had an 8-year-old child. On examination, he...

Introduction: Obesity related glomerulopathy (ORG) is an emerging epidemic alongside increasing incidences of obesity. ORG pathophysiology has not been explored despite poor prognosis in untreated patients. MCP-1, MIF, CCL-18 and CCL-15 are novel cytokines that may be pathologically involved in obesity-induced renal injury and explored in this study.Methods: Blood pressure, urine and blood samples were collected from 34 morbidly obese patients before and...

Introduction: There is a general assumption that glycemic control in persons with diabetes(PWD) has deteriorated since the onset of COVID-19 pandemic. We conducted this to compare the glycemic status of a very large cohort of PWD prior to COVID-19 outbreak with that of a similar cohort post onset of the outbreak. Methods: This was a retrospective study wherein entire data of glycated hemoglobin (HbA1c)% available in the hospital database since 3rd Octobe...

Hemoglobin A1c (HbA1c) is formed from the addition of a glucose residue to the N terminus of the Beta chain of a hemoglobin molecule via a non-enzymatic glycation pathway. Its levels correlate with the ambient plasma glucose concentration. The 120-day life span of red blood cells makes HbA1c a useful tool to approximate the diabetic control of patients over three to four months. It has also been found to be an accurate predictor of the microvascular and macrovascular complicat...