Endocrine Abstracts

Aims and objectives: Poor attendance in clinics remains a concern shared by diabetes services nationally and internationally. We surveyed our children’s diabetes service users to identify local reasons for non-attendance. We used the opportunity to seek feedback from service users about service design.Study population group: The group included parents/carers of children and young people who use children’s diabetes service delivered by Walsall H...

Background: Recent evidence favours the use of TRAB in patients with hyperthyroidism (a) at presentation to identify the aetiology and predict outcomes (b) at the time of withdrawal of medical therapy to predict remission and (c) during pregnancy. However, If TRAB is not requested at an appropriate time, it may not help, may mislead or add to cost.Aim: To review the current process of requesting TRAB in line with available evidence and identify areas for...

Presentation: A 32-year-old woman was brought to the Emergency Department following an out-of-hospital cardiac arrest. CPR was started by a neighbour and on arrival, she was found to be in ventricular fibrillation (VF). She received 4 DC-shocks and reverted to atrial fibrillation with fast ventricular rate and staged a full cognitive and haemodynamic recovery. She had a 10-year history of Graves’ thyrotoxicosis for which she was on Carbimazole but remained uncontrolled du...

Endometriosis is one of the commonly occurring disorders of reproductive women, which represents attachment of functional endometrial cells and tissue outside the uterine cavity, culminates into infertility. This invasive disorder is still under quest for novel treatment strategies. Naringenin is a plant-derived flavonoid having anti-proliferative, anti-inflammatory, and anti-angiogenic properties in chronic and metabolic diseases. The study was planned with an objective to de...

Introduction: Many people with type 1 diabetes continue to experience suboptimal glycaemic control. We now also know that often HbA1c levels are an inaccurate reflection of glycaemic patterns and variability. We describe here how the systematic use of the FreeStyle Libre flash monitor helped improve the glycaemic control of many people with type 1 diabetes.Methods: We report the outcomes of 92 consecutive adults (18 years of age or more) with type 1 diab...

Thyroid hormones (TH) are required for normal postnatal growth development in mammals. The physiological importance of TH becomes evident under the conditions of congenital–neonatal hypothyroidism (CH). If not treated immediately, CH has a profound impact on physiology and can permanently imprint neurological and endocrine systems, which, in turn, led to mental retardation, growth arrest, and metabolic disturbances. A delayed growth development or long-lasting influence o...

Introduction and Objective: Pheochromocytomas are usually monocomponent tumors, but very rarely there are also composite pheochromocytomas, with another medullary component (benign or malignant) derived from the neural crest present. Even more rarely there are mixed corticomedullary tumors, with pheochromocytoma plus a cortical adrenal tumor, eventually causing primary aldosteronism or hypercortisolim. Our objective in this communication is to illustrate an infrequent variety ...

Introduction and Objectives: Extended-release (ER) metformin may reduce the gastrointestinal adverse effects of conventional metformin, increasing compliance, adherence and persistence. In mid 2022, a single-pill combination (SPC) containing 50 mg sitagliptin plus 1000 mg ER metformin was released in Spain, while monocomponent ER metformin is still unavailable. We rechallenged patients with T2DM labelled as metformin-intolerant and treated with a DPP4i with the mentioned SPC i...

Introduction: The differential diagnosis between arginine vasopressin deficiency (AVP-D), formally known as central diabetes insipidus, and primary polydipsia (PP) is challenging. In clinical routine, psychopathologic findings are often used as a hallmark for diagnosing PP; thus, it is often referred to as psychogenic polydipsia. Yet, psychopathologic characteristics are barely assessed in patients with AVP-D, and to date, no data exist comparing AVP-D and PP with regard to th...

A 56-year-old Swedish male was diagnosed with hypertension, initially attributed to continued use of NSAIDs. These were withdrawn and treatment with 80 mg valsartan was started, but BP remained uncontrolled. A fixed combination (valsartan/hydrochlorothiazide, 80/12.5 mg) was introduced, but blood pressure remained high and hypokalemia (K+3.3 mEq/l) developed. The patient was referred to our Endocrinology Clinic for study. Treatment was switched to manidipine 10 mg/1...