Endocrine Abstracts

Background: Radiolabeled somatostatin analogs provide a means of delivering targeted radiation with a high therapeutic index to NETs that express somatostatin receptors (SSTRs). We hypothesize that the addition of an effective radiation sensitizer could help improve the antitumor activity of Lutathera. Radiation is a potent inducer of DNA damage. The primary repair mechanism of radiation-induced double-stranded breaks (DSBs) is the nonhomologous end-joining (NHEJ) pathway, in ...

Background: William-Beuren region duplication syndrome (WBDS) is a rare multisystem disease caused by the gain on chromosome 7q and transmitted autosomal dominant, with approximately a population frequency of 1 in 13,000-20,000. The age of diagnosis is variable, but generally, it is diagnosed during childhood. It include endocrine (growth hormone deficiency) and non-endocrine (facial dysmorphology, cardiovascular problems, gastrointestinal and genitourinary problems, neurologi...

We have come a long way in the UK over the past ten years towards our goal of meeting the educational needs of nurses specialising in adult endocrinology. Endocrine nurses are now able to access annual training updates and attend specific nurse-led sessions at scientific meetings thanks to the ongoing work undertaken by the Society for Endocrinology’s nurse committee.It is therefore time to turn our attention to how we can encourage nurses to want t...

We have come a long way in the last ten years towards meeting the educational needs of nurses specialising in adult endocrinology. Endocrine nurses are now able to access annual training courses (renamed updates in 2010) and attend specific nurse-led sessions at scientific meetings thanks to the ongoing work undertaken by the Society for Endocrinology’s nurse committee. It is therefore time to turn our attention to how we can encourage nurses to want to specialise in endo...

Historically, many endocrine specialist nurses (ESN) worked in ‘isolation’, with little peer support, ‘learning on the job’, there were few external training opportunities and their roles developed according to local expectations and needs.In 1997, a small group of ESN met to establish a support network for themselves and their colleagues. Within a year they had successfully developed links with the Society for Endocrinology (S for E)...

The low incidence of acromegaly makes it difficult for any individual centre to gather prospective data on a large enough series of patients to enable satisfactory epidemiological and other research to take place. In 1998, eight centres agreed to set up a collaborative database with a view to accumulating a major series covering the main treatment centres. The project has now been active for several years and there are currently seventeen participating centres. Any centre that...

Currently in the UK children and young people with diabetes receive variable provision of care and support in educational settings. There are concerns that this impacts on the young person’s glycaemic control, their quality of life, and their educational performance and outcome. Whilst most paediatric diabetes teams provide training for school staff, it may take several days, even weeks, after diagnosis before a diabetes educator is able to attend the school to provide ed...

We have come a long way in the UK over the past ten years towards our goal of meeting the educational needs of nurses specialising in adult endocrinology. Endocrine nurses are now able to access annual training updates and attend specific nurse-led sessions at scientific meetings thanks to the ongoing work undertaken by the Society for Endocrinology’s nurse committee.It is therefore time to turn our attention to how we can encourage nurses to want t...

Background: Congenital adrenal hyperplasia (CAH) is an autosomal recessive condition with significant consequences if not correctly diagnosed and treated. We have reviewed the patients with CAH presenting in Northern Ireland between 1976 and 2010.Aims: To determine the age, sex and clinical features at presentation; treatment modalities including perineal surgery in childhood; and long-term outcomes including final height and surgery in adulthood.<p ...

The Pituitary Foundation was founded in 1994 when a group of endocrinologists, GPs and patients identified the need for a support group for patients with pituitary disease. Charitable status followed in 1996. It's core aims are to provide support to patients, their families and carers, to act as a source of reliable information and to increase awareness of the Foundation and pituitary disease within the medical profession and the general public. Membership, services and public...