Endocrine Abstracts

Introduction: Calcific Uremic Arteriolopathy (CUA) is a rare but severe complication of end-stage kidney disease with one year survival rates between 45-55%. Extensive skin ulcers and concomitant painful purpura are the clinical features and diagnosis criteria as defined by Hayashi. Parathyroidectomy treatment for hyperparatiroidism is reserved for patients with inadequate response to calcimimetics, persistent elevated PTH>800 pg/ml or calciphylaxis and it has been shown t...

Background and aims: The prevalence of gestational diabetes (GDM) increases worldwide with rates between 9 and 35%. The management of GDM is a labor-intensive discipline, in which the global increase in GDM prevalence poses challenges to maintain high-quality care. A valuable solution could be the organization of group education. The ELENA study therefore aimed to evaluate women’s satisfaction about (group) education and treatment, their knowledge about GDM and whether th...

Hurthle cell carcinoma (HCC) represents about 5% of differentiated thyroid carcinomas. When Hurtle cell represents more than 75% of cells population, the lesion can be considered a Hurthle cell tumor (HCT); it can be classify as malignant when capsular or vascular invasion is reported or if there is a perithyroid infiltration or distant metastases occur. Aim of this study was to present our own experience on the clinical and pathological features of patients (pts) affected by ...

The aim of the present study was to determine the change of fasting serum leptin and insulin levels and insulin resistance in patients with risk factors of diabetes mellitus of type 2 (DM 2) including impaired glucose tolerance/impaired fasting glucose (IGT/IFG), obese and first-degree relatives of patients with diabetes after lifestyle modification.Material and methods: The study included 100 patients (32 men, 68 female) 25–65 years old at risk fac...

High doses of anabolic-androgenic steroids (AAS), especially when taken concomitantly with multiple other preparations, can lead to a decrease in high-density lipoprotein (HDL) cholesterol and an increase in low-density lipoprotein (LDL) cholesterol. After long-term, high-dose AAS abuse, atherosclerosis may develop, leading to coronary artery disease, cerebral vascular disease or peripheral artery disease. The degree of atherosclerosis appears to be dependent on the duration o...

Today diabetes (DM) is one of the largest global health emergencies. Each year a large number people live with this condition. Currently there are more than 422 mln people with DM worldwide. DM is one of the major public health problems in Georgia. Number of people with DM is on the rise, though no exact statistical data for Georgia exist. Diabetes Atlas (International Diabetes Federation, 2015) gives diabetes prevalence for Georgia of 7.9%, though these data are extrapolated ...

Recent evidence suggests that resolution of hypercortisolism in Cushing’s disease (CD) may not lead to complete remission of the clinical abnormalities associated with this condition. In particular, elevated cardiovascular risk may persist in ‘cured’ CD patients long-term after eucortisolism has been achieved. This is believed to be related with the maintenance of visceral obesity and altered adipokine secretory pattern which perpetuate features of metabolic syn...

Objective of the study was to analyse the relationship of compensation, lipid profile parameters and androgenic status in patients with type 1 (DM1) depending on the duration of diabetes. There were examined 76 men with DM1 aged 20–49 years (mean age 35.8±8.2) and duration of diabetes more than a year. The control group consisted of 25 healthy men aged 21–41 years (mean age 34.6±7.8). Compensation of diabetes was assessed by the level of HbA1c. Also there w...

During the last years, bone turnover markers (BTMs) have gained importance as surrogate markers to monitor both anti-resorptive and anabolic treatment, and may be used in conjunction with bone mineral density (BMD) measurements in clinical practice. The two most widely utilized BTMs are pro-collagen type 1 N-terminal propeptide (PINP), which reflects osteoblast activity, and C-terminal-cross-linking telopeptide of type 1 collagen (CTX), which corresponds to the osteoclastic fu...

Introduction: Systemic mastocytosis is a form of mastocytosis in which mast cells accumulate in tissues and organs such as liver, spleen, bone and small intestines. Symptoms and signs differ based on which parts of the body are affected and vary from asymptomatic forms to highly aggresive forms with low survival rate. About 16% of patients with systemic mastocytosis have symptomatic fractures, but the presentation of systemic mastocytosis with vertebral fractures as first clin...