Endocrine Abstracts

Introduction: Follicular thyroid carcinomas (FTC) are the second most common type of thyroid malignancy. Micro-RNAs (miRNAs) are a new class of small, noncoding RNAs whose expression is deregulated in many types of human cancers and may lend novel clues to FTC genesis. Pre-miR146a represents one of the most up-regulated miRNAs in papillary thyroid carcinomas (PTC) and a SNP (rs2910164), identified in pre-miR146a, contributes to genetic predisposition to PTC, but data on FTC ar...

Background: The treatment landscape for neuroendocrine tumors includes alkylating-agent chemotherapy and peptide receptor radiotherapy (PRRT) with 177Lu-Dotatate. The risk of MDS/AML associated with 177Lu-Dotatate is approximately 2-3%. Several small prior studies have suggested substantially higher rates of MDS/AML (approximately 10%) in patients who have also received alkylating agent chemotherapy with streptozocin or temozolomide, either combined with PRRT or sequentially. ...

Context: Lipodystrophy is characterized by subcutaneous fat loss, fat maldistribution, and metabolic syndrome. We present a novel phenotype of partial acquired lipodystrophy, possibly associated with childhood chemotherapy.Case reports: Two adult female patients that had been exposed to intensive cytostatic treatment in childhood for leukemia and aplastic anemia, respectively, were referred for therapy resistant diabetes. Both patients had distinct parti...

Little is known about the negative regulation of angiogenesis in the ovary. Recent evidence has revealed that estradiol 17β and its metabolites may play an important role in this fine tuning1. In a previous work2, we set up an assay to quantify 2-hydroxyestradiol (2-OHE) and 4-hydroxyestradiol (4-OHE) in follicular fuids. In order to get an insight on the angiogenic effect of 4-OHE and 2-OHE, the objective of this research was to study their possible...

Neuroendocrine tumors (NETs) are rare neoplasms showing a wide spectrum of clinical behaviors. The therapeutic options available for NET treatment are rarely curative and most are palliative, as NETs frequently show resistance to pharmacological therapy. Cancers develop in complex tissue environments, which they depend upon for sustained growth, invasion and metastasis. A major characteristic of the tumor microenvironment is inflammatory cell infiltration, where tumor-associat...

Background: Gastric neuroendocrine tumors are rare neoplasms, comprising approximately 2% of all gastric tumors, and develop from enterochromaffin-like (ECL) cells in the gastric mucosa. Type I and II develop due to hypergastrinemia and ECL cell hyperplasia; type III typically occur sporadically, tend to be more aggressive, present metastatically in > 50% of cases, have normal fasting gastrin levels, and vary histopathologically from well- to poorly differentiated tumors. ...

Background: Glucocorticoids are crucial for treating various medical conditions due to their beneficial immunosuppressive effects. However, glucocorticoids also carry a high risk for osteoporosis. Notably, within just a few months of glucocorticoid therapy, bone density can be significantly reduced, and up to 5% of patients undergoing such treatment may experience fractures. There is promising evidence from preclinical studies and observations in patients with type 2 diabetes ...

Introduction: The intricate interplay between fibroblasts and cancer cells significantly contributes to cancer invasion, extracellular matrix (ECM) modulation, and the development of drmg resistance. This study delves into understanding the specific influence of fibroblasts on Gastro-Intestinal neuroendocrine tumor (GI-NET) cell lines.Materials and Methods: Utilizing GOT1 and COLO320 cell lines, we incorporated Normal Human Dermal Fibroblasts (NF) in our...

Introduction: Type 1 diabetes results from autoimmune destruction of pancreatic beta cells and requires lifetime insulin treatment. Poor glycemic control may worsen sleep quality in people with diabetes and poor sleep quality may worsen glycemic control by increasing insulin resistance, which could further lead to an overall worsening of the quality of life in diabetes. Technology use in diabetes improves glycemic control and in pediatric populations, it has been shown to impr...

Background: Vandetanib and Cabozantinib are the only two multitarget tyrosine kinase inhibitors approved for the management of metastatic and progressive medullary thyroid cancer. (MTC) Despite their efficacy in terms of progression free survival prolongation and overall response rate, the drug-related toxicity is still a clinical problem, impairing patient’s quality of life and the compliance to the treatment. We retrospectively evaluate the adverse events (AEs) occurred...