Endocrine Abstracts

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Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA), and the same trend is observed in the national quality indicator. The validity of electronic databases and quality indicators are limited by multiple discharges and precision of coding. Furthermore, amputation codes included in the quality indicator do not include all amputations. We therefore aim to investigate the ...

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA). However, our findings suggest that the proportion of diabetics among patients undergoing non-traumatic, non-cancer related lower limb amputations has increased over the past decades despite comprehensive preoperative investigations and other surgical interventions. To further explore the underlying reasons for this, ...

Introduction: Bile acid malabsorption (BAM) may be a contributing factor causing diarrhoea in patients with NETs, particularly among those who have undergone previous surgical resection of the terminal ileum and/or right colon or cholecystectomy (Naraev et al 2019). Aim(s): To identify the prevalence of bile acid malabsorption in neuroendocrine tumour patients (NET) at the Queen Elizabeth Hospital Birmingham (QEHB). Materi...

Background: Current dogma states that in autoimmune Addison’s disease (AAD), all adrenocortical function eventually is lost. Yet growing evidence suggests that a subgroup of patients retain some self-production.Aim: To explore whether residual production of adrenocortical steroids is present in a subgroup of AAD patients.Material and methods: In an open non-randomized cross-sectional study, an interim of 22 AAD patients delive...

Background: Previous research show that autoimmune adrenal insufficiency develops gradually over time and inexorably results in a total inability to produce adrenal steroids. However, growing evidence suggest that a few patients preserve some steroid producing capacity.Aim: To explore the frequency of residual cortisol production and possible clinical consequences in patients with autoimmune Addison´s disease (AAD).Material an...

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addison’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...

Background: Obesity (BMI< 30 kg/m2) is a chronic and progressive disease, that is associated with many co-morbidities such as cardiovascular and psychiatric diseases, cancer, and arthritis. Lifestyle interventions are the cornerstone of obesity treatment, but when ineffective, anti-obesity pharmacotherapy could be added. In recent years, several anti-obesity agents have been approved, such as the glucagon-like peptide -1 (GLP-1) analogue liraglutide. Liraglutide...

Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. In women, vitamin D status has been associated with in vitro fertilization (IVF) outcome, features of polycystic ovarian syndrome (PCOS), endometriosis, and sex hormone steroidogenesis. In detail, cross-sectional data suggest a regulatory role of vitamin D in PCOS-related aspects such as ovulatory dysfunction, insulin re...

Background: In the UK, adults with growth hormone deficiency (GHD) are treated with recombinant Growth Hormone (GH) therapy according to NICE guidelines (TA64). Provided that patients show an initial improvement in their quality-of-life score, assessed using the Quality-of-Life Assessment of GHD in Adults (Qol-AGHDA) questionnaire, they can continue with their GH treatment long-term. However, in clinical practice, many patients are observed to discontinue GH r...