Endocrine Abstracts

INTRODUCTIONThe plasma concentrations and urinary excretion rates of 18-OH-F and 18-oxo-F are high in Conn's syndrome and glucocorticoid suppressible hyperaldosteronism, reputedly because aldosterone synthase (AS) has abnormal access to cortisol (F). However, both compounds are also excreted in normal subjects. Two enzymes, 11beta-hydroxylase (11OH) and AS, located in the zona fasiculata (ZF) and zona glomerulosa (ZG) respectively, are capable of 18-hydroxylation but only ...

Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...

Background: Evaluation of plantar pressure is useful for detecting functional abnormality of foot, especially in diabetic patients. The aim of this study was to evaluate plantar pressure and force in diabetic patients using Tekscan F-Scan in-shoe foot force and gait analysis system.Methods: Plantar pressure and force were measured by selecting an area of interest under the six areas of the foot: hallux, first metatarsal, second metatarsal, 3–5 metat...

Archipelago/hCdc4/Fbw7 is the F-box protein specific for recognising and binding phosphorylated cyclin E and targeting it for ubiquitination. Mutations in Archipelago that prevent it from binding to phoshorylated cyclin E have been described in various human cancers including breast, ovarian and endometrial tumours. Previous studies have suggested that cyclin E is over-expressed in corticotroph tumours and other pituitary adenoma subtypes, and we postulated that this may be se...

Background: In case of inoperable disease or tumor recurrence, there are only a few medical treatment options for patients with adrenocortical carcinoma (ACC). The oral alkylating drug Temozolomide (TMZ) shows efficacy in a subset of patients with melanoma, glioblastoma or pancreatic neurendocrine tumours. Response to TMZ seems determined by the tumoral expression level of the DNA repair enzyme O(6)-Methylguanine-DNA methyltransferase (MGMT).Aims: To eva...

Introduction: Although numerous noninvasive markers are being used in order to determine preoperative thyroid cancer risk in patients with multi-nodular goiter, none of them are optimal. The objective of this study was to compare retrospectively the TSH level between two groups of subjects who underwent total thyroidectomy for a nodule and whose final histology was benign or malignant.Methods: Our study included 208 patients that underwent thyroidectomy ...

Background: We have previously shown that a higher BMI and less favorable body composition are associated with relatively higher FT3 levels (within the euthyroid range) in healthy young men. In this study, we aimed to investigate whether FT3 and the ratio FT3:FT4 are also associated with cardiovascular markers in a healthy euthyroid population of middle-aged men and women.Methods: Thyroid parameters were measur...

In the ovary, 11βHSD enzymes inter-convert cortisol (F) with its inert metabolite, cortisone (E). Porcine follicular fluid from antral follicles and spontaneous ovarian cysts contains hydrophobic compounds that inhibit NADP(H)-dependent cortisol metabolism by 11βHSD1. The aim of this study was to measure intra-follicular F:E ratios in porcine antral follicles and ovarian cysts, and determine whether F:E ratios correlate with the inhibition of 11βHSD1 by porcine ...

Introduction: Helicobacter pylori (HP) infection is the most significant cause of gastritis and related morbidities. Radioactive iodine treatment (RAIT) is an important option in the treatment of hyperthyroidism. In addition to thyroid gland, RAI accumulates in stomach in significant amounts. In our study, we planned to investigate whether RAIT has an effect on carbon-14-urea breath test (UBT) in patients with hyperthyroidism.Materials-method: The...

Introduction: It is commonly known that hearing and balance functions are affected in thyroid function disorders. In literature, there are very few studies demonstrating that hearing may be affected due to autoimmunity in euthyroid Hashimoto’s thyroiditis (HT) independent from thyroid functions. In addition, hearing disorders have also been reported in other autoimmune diseases. For this reason, we investigated the functions of the peripheral and central sections of audit...