Endocrine Abstracts

Background: The increasing age of the general population represents a new challenge for endocrinologists and caregivers since it is well know that the occurrence of thyroid dysfunction increases with age. It is still controversial whether or not reference values of thyrotropin (TSH) adapted to age and sex need to be used. Herein, we aimed to determine reference intervals, in males and females, suitable for thyroid disease exploration and follow-up during adult life in a tertia...

CaSR-autoantibodies may cause auto-immune hypercalcemia through either simple blocking or biased properties. The phenotype of this rare disease is most often acquired hypocalciuric hypercalcemia (AAH) (Minanbres JCEM 2020, Makita JCI insight 2022), but sometimes hyperparathyroidism (Pelletier-Morel Intern Med 2008), in elderly. Gender, auto-immune context is variable. Blood calcium may fluctuate, and acute exacerbations may be successfully treated with predni...

Introduction: DOTANOC is a largely used somatostatin analogue in NETs investigations. In NODAGANOC, the DOTA is replaced by NODAGA, a chelator derivative from NOTA which is the ‘gold standard’ for Ga3+ and Cu2+ chelation because it forms more stable complexes than DOTA.[1] The aim of our study is to evaluate the affinity of NODAGANOC for somatostatin receptors (sst) and to develop a 68Ga and 64Cu labelled NODAGANOC for a fu...

Introduction: Pheochromocytoma is a catecholamine-secreting neuroendocrine tumor arising from the chromaffin cells of the adrenal medulla. It is rare and considered benign, but can be life-threatening in the event of catecholaminergic discharge. Tumors differ in genotype, mechanism of tumorigenesis and type of secretion. On imaging, it is often characterized by central intra-tumor necrosis; there is very little data in the literature on the genesis and pathophysiological role ...

Introduction: Nonfunctioning pituitary adenomas (NFPAs) are a heterogeneous group of tumors with different presentations. Clinical management of these tumors is complex. Our aim was to evaluate the clinical characteristics/postsurgical outcomes of NFPAs and to identify predictive factors of good response to surgery.Methods: Retrospective analysis of NFPA, who underwent surgery and followed in our hospital, from 2015-2022.Results: W...

Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including DHEAS, the inactive sulfate ester of the adrenal androgen precursor DHEA. Deficient DHEA sulfation, the opposite enzymatic reaction to that catalysed by STS, results in androgen excess by increased conversion of DHEA to active androgens. STS deficiency (STSD) due to deletions or inactivating mutations in the X-linked STS gene manifests with ichthyosis, but androgen homeostasis in STSD h...

Background: Papillary craniopharyngiomas (PCPs) are driven by V600E BRAF mutations in 95% of cases. Recently, combined anti-BRAF/MEK targeted therapy (TT) has emerged as a potential treatment in aggressive PCPs. However, standardized data on large cohorts are still lacking. Our study aimed to assess the real-life efficacy and safety of TT in patients with PCPs.Methods: This was a retrospective national multicenter study involving patients with V600E BRAF...

Background: APECED syndrome is a rare monogenic disease caused by homozygous mutation of AIRE gene. It classically presents with chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HP), and adrenal insufficiency (AI) with an early onset in childhood. Non-endocrine manifestations as ectodermic dystrophy, asplenism and pneumonitis are also observed but their incidence remains unknown and their mechanisms not well understood. APECED has been poorly reported in France alt...

Among androgen deprivation therapy (ADT), radiation therapy is an approved treatment either for early stage local PCa, but also for metastatic M1 stage PCa. However, tumour relapse is a frequent event that affects about 80% of patients undergoing prior treatment. There is increasing evidence that the occurrence of cancer stem cells (CSC) may play an important role in therapy resistance, in particular also in radioresistance. However, our knowledge on the mechanisms of radiores...

Primary hyperaldosteronism is now recognised as the most frequent underlying cause of hypertension. We recruited 94 patients (age (mean±S.D.) 56±11 years) with hypertension from primary care in order to study the role of corticosteroid hormone action in this cohort. Random, blood pressure (BP), plasma renin activity (PRA) and aldosterone (Aldo) was measured both on and off antihypertensive medication. In addition, a 24 h ambulatory blood pressure (ABP)...