Endocrine Abstracts

Fat accumulation, lipogenesis and glycolysis are key contributors to hepatocyte metabolic reprogramming and the pathogenesis of non-alcoholic liver fatty liver disease (NAFLD). The molecular mechanisms affected by steatosis and inflammation in the obese state remain unknown. Here we report that obesity leads to dysregulated expression of protein-tyrosine phosphatases in human livers. Protein Tyrosine Phosphatase Receptor Kappa (PTPRK) levels were increased in hepatocytes by st...

Introduction: The thyroid gland and COVID-19 infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. Until now, the evidence on the outcome of COVID-19 in patients with a history of thyroid cancer remains scarce, and most of the recommendations given are based on common sense.Case report: A 71-year-old man was admitted to Mikaelyan University hospital with general weakness shortness of breath, hiccup and ...

Type 1 diabetes mellitus (T1DM) is one of the most frequent autoimmune disorders in childhood, adolescence and youth, developing due to autoimmune destruction of pancreatic β-cells, which leads to an absolute insulin deficiency. Gut microbiota (GM) is associated with the functions of the body’s immune system, and immune-mediated diseases, including T1DM. However, the exact mechanisms by which GM is involved in the T1DM are still unknown. Accumulating data suggest tha...

Introduction: Incidence of type 1 diabetes mellitus (T1DM) is rising steadily around the globe, including Armenia. It is one of the most common autoimmune and metabolic disorders in pediatric population, resulting from autoimmune destruction of pancreatic β-cells leading to insulin deficiency. Gut microbiota (GM) is reportedly involved in the pathogenesis of T1DM likely by influencing the immune response with the help of arginine-metabolizing enzymes. Arginase i...

Introduction: Type 1 diabetes (T1DM) is one of the most frequent autoimmune and metabolic disorders in childhood and youth, developing due to autoimmune destruction of β-cells, which leads to an absolute insulin deficiency. Accumulating data suggest that gut microbiota (GM) may contribute to the pathogenesis of diabetes influencing the immune response, in which arginine-metabolizing enzymes are involved, particularly arginase. We examined the connection between GM and cyt...

Background: Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body (Sergeant et al., 2012). Single nucleotide polymorphism (SNP) in FADS1 gene and percentage of polyunsaturated fatty acids inserum lipids was associated (Klingel et al., 2018). Genetically predisposition to higher plasma arachidonic and stearic acid levels were associated with incidence oflarge-artery stroke and venous thromboembolism...