Endocrine Abstracts

Antithyroid drugs represent mainly the first choice therapy in hyperthyroid Graves’ disease. Their therapeutical ineffectiveness can lead to the onset or the severity of ophthalmopathy associated with Graves’ disease. Type 2 5’-deiodinase enzyme (DIO2) plays a crucial role besides type 1 5’-deiodinase enzyme in the development of Graves’ hyperthyroidism. Anti-thyroid drugs inhibit the activity of both type 5’-deiodinases blocking the synthesis of ...

Optogenetics is the combination of genetic and optical methods to control specific events in live cells with high temporal and spatial precision. In 2010, optogenetics was chosen as the Method of the Year across all fields of science and engineering by Nature Methods. Two methods for the photocontrolled activation of apoptosis in cancer cells will be contrasted; one that relies on the development of externally administered biophotonic nanoswitches and the second, in which the ...

Epidemiological observations increasingly imply nutritional energy balance as a key risk factor for cancer development. Excess body weight is associated with increased risks of cancers of the endometrium, breast (postmenopausal women), kidney (renal cell tumours), colon, pancreas and oesophagus (adenocarcinomas). By contrast, regular physical activity reduces the risk of developing breast and colorectal cancers, and potentially other tumour types. Overall, excess weight and la...

The incidence of Graves disease in different regions of Russia ranges from 20 to 50 cases per 100000 population.Purpose: To improve the results of surgical treatment of patients with Graves disease by identifying the optimum amount of remaining thyroid tissue and prediction of thyroidal status in the long term.Methods and design: The 138 patients with Graves disease operated over the past 10 years: 131 women (94.9%) and 7 men (5.1%...

Aim: To develop non-invasive cytochemical diagnostic technique and monitoring of compensation of diabetes mellitus type 2.Materials and methods: Material for cytological and cytochemical analyses was oral swab cheek in 22 healthy people and 33 sick ones with type 2 diabetes mellitus at sub compensation stage. The group under study was homogenous in age (45–65 years), sex (men) and biorhythmic type. Experiments were performed on human subjects and lo...

Material for cytological analysis was oral swab of investing type (lip, cheek) in 22 healthy people and 33 sick ones with type 2 diabetes mellitus at sub compensational stage. The group under study was homogenous in age (45–65), sex (men) and biorhythmic type. Experiments were performed on human subjects and local Ethical Committee approval was obtained. Oral swabs were fixed in spirit–acetone and were May–Grunvald’s and Romanovsky–Gimsa’s dyed. T...

Background: Spinal muscular atrophy (SMA) is hereditary, degenerative, neuro-muscular disease of lower motor neurone that leads to muscle weakness and atrophy. Several metabolic disturbances such as impaired glucose tolerance (IGT), insulin resistance (IR), hypoglycaemia and dyslipidaemia can be present. Most studies were done in children, with more severe forms of SMA. We aimed to assess body composition, IR, glucose and lipid metabolism in adult patients with SMA type 2 and ...

Introduction: Pituicytoma is a rare neoplasm of the sellar region, believed to originate from neurohypophyseal cells. Tumor resection is the primary treatment option, but may remain incomplete due to excessive bleeding of the well vascluarized tumor stroma. Therefore the search for alternative or additional treatment regimens is necessary. In a previous publication in 2012 the presence of VEGF-R was shown in one tumor sample, potentially opening the door for modern treatment o...

Background: Thermoregulatory disorders after neurosurgery of craniopharingyomas were seldom reported.Aim: To present the difficulties of etiologic diagnosis and treatment of a persistent febrile syndrome in a patient with surgically removed craniopharyngioma.Patient and methods: A 34 years old man with a giant craniopharyngioma situated in the basal-anterior part of the third ventricle is reported. Anterior pituitary hormones were ...

Introduction: Diagnostic imaging of neuroendocrine tumors (NETs) is the domain of somatostatin receptor (SSTR) agonists as well as FDG PET/CT in dedifferentiated tumors. SSTR also serves as target for receptor directed peptide therapy. More recently, specific ligands targeting the chemokine receptor 4 (CXCR4) were introduced potentially offering an additional theranostic option in NETs. Here we evaluated the CXCR4 expression using 68Ga-Pentixafor PET/CT in NET patie...