Endocrine Abstracts

Background: Hobnail variant of papillary thyroid carcinoma (HPTC) has been recently identified. Given the rarity of the variant its characteristics have been studied only in little series, limiting the quality of the data available for its better management. The aims of our retrospective study were 1) to define the clinical and molecular characteristics of a series of HPTC in a monocentric and relatively large series; 2) to define the clinical and molecular characteristics abl...

Background: Follicular-derived thyroid cancers (FDTC) generally have a good prognosis. Nonetheless, a minority of them have an aggressive behavior and develop distant metastases, with increased mortality rates. Pre-surgically available prognostic markers, able to identify this group of patients are still lacking.Materials and methods: The study involved 436 FNA samples with a malignant/suspicious cytology obtained from thyroid nodules in 436 consecutive ...

Background: Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid gland, accounting for 74–80% of all thyroid cancers. The T1799T>A transversion is an activating mutation of the BRAF oncogene that is common in conventional PTC and specific to it.Aims: To study the prevalence, tumorigenic role and biomolecular implications of rare BRAF variants in a large cohort of patients.Study desig...

We conducted a survey during the first pandemic wave of coronavirus disease 2019 (COVID-19) on a large group of osteoporotic patients to evaluate the general conditions of osteoporotic patients and the impact of the pandemic on the management of osteoporosis, finding high compliance to treatments and low COVID-19 lethality. In a telephone survey conducted from April to May 2020, patients from the Osteoporosis Center, Clinic of Endocrinology and Metabolic Diseases of Umberto I ...

Abstract: An individualized risk-based approach to the treatment of thyroid cancer is being extensively discussed in the recent literature, but controversies remain about the ideal surgical approach. In particular, if some data showed that properly selected thyroid cancer patients can be treated with lobectomy (LT) with excellent clinical outcomes, other results demonstrated an increased incidence of persistent recurrent disease in patients submitted to LT with respect to thos...

Background: COVID-19 pandemic is a novel, potentially adverse condition for patients with adrenal insufficiency (AI), whose life expectancy and quality of life (QoL) are impaired due to their risk of infections and stress-triggered acute events. Therapeutic usefulness of glucocorticoids in COVID-19 is debated, but infected AI patients require prompt replacement tailoring.Objectives: In a cohort of AI patients, to assess:– the...

Background: Dysnatremia is common in hospitalized patients, often worsening the prognosis in pneumopathies and critical illnesses, such as COVID-19. Here, hyponatremia is an indicator of pulmonary involvement, while hypernatremia is associated with worse assistance outcomes, particularly when resulting from an overcorrected hyponatremia. Longer hospitalizations, readmissions after discharge and higher short- and long-term mortality rates have been observed in acute patients ex...

The aryl hydrocarbon receptor interacting protein (AIP) gene is abundantly expressed in normal somatotrophs. Somatotropinomas in patients with germline AIP mutations (AIPmut) are typically more aggressive than non-AIPmut adenomas and associated with higher GH/IGF1 secretion. AIP downregulation may also occur in sporadic somatotropinomas, especially in invasive tumours. We wished to evaluate the impact of somatostatin analogues (SSA) pre-treatment on AIP expression in sporadic ...

Objective: The management of male idiopathic infertility is challenging. The Italian Medicines Agency (AIFA) note 74 regulates the empirical administration of follicle-stimulating hormone (FSH), although its application in clinical practice remain conflicting. The aim was to explore the management of male idiopathic infertility and to assess the actual use of FSH.Methods: A multicenter longitudinal prospective observational study (open-registry), involvi...