Endocrine Abstracts

Background: Pancreatic mixed acinar-neuroendocrine carcinomas are a rare distinctive entity with histologic and immunohistochemical features of pancreatic acinar cell carcinoma and pancreatic neuroendocrine tumor and pose diagnostic challenges. Very few cases have been described in the literature. Genomic information about these tumors remains unknown. We identified two cases of mixed acinar- neuroendocrine carcinoma from our database since January 2020 who had full genomic in...

Introduction: Green tea consumption has been reported to be associated with weight loss although the results of the studies are inconclusive and potential underlying mechanism is not yet clear. We aimed to evaluate the effect of green tea extract on weight loss, body composition and resting energy expenditure in obesity.Methods: Twenty-nine obese patients (body mass index (BMI) >30 kg/m2) were included in the study. Weight, BMI, waist circ...

The aim of our study was to examine the influence of green tea molecules on basic ovarian functions. For this purpose we have examine the effect of green tea extract, fraction of antioxidants (GTAO) and green tea fraction of polyphenols (GTPP) (at the doses 0, 1, 10, and 100 μg/ml) on proliferation, apoptosis, and steroidogenesis by cultured porcine ovarian granulosa cells. Markers of proliferation (PCNA) and apoptosis (bax) were detected by immunocytochemistry. Secretion...

Background: Hypertension, obesity and hyperlipidemia are key interlinked features of both metabolic syndrome and cardiovascular disease. Numerous studies have suggested that green tea may reduce blood pressure by activating endothelial nitric oxide synthase and reducing total cholesterol by disrupting the production of apo B and synthesis of chylomicrons and thus have cardio-protective effects. The aim of this pilot study was to investigate the effects of increasing the consum...

Obesity is considered as an exceeding life style disorder notably in developing countries and it is prevailing at a frightful speed in new world countries as a result of fast food intake, causing raised blood cholesterol levels, which in turn can damage many systems in the body. The present study investigates the hypolipidemic effects of sulphated polysaccharide obtained from Codium fragile (CFSP) in induced obese rats (HFD). The results showed an increase in body weight of HF...

Background: We have recently shown that consumption of green coffee bean extract rich in chlorogenic acid reduces blood pressure and urinary free cortisol levels1. Increased 11β HSD1 (Hydroxysteroid dehydrogenase type1) activity is implicated in the development of obesity, cardiovascular disease and diabetes. The aim of this study was to compare the effects of consuming green (GC) and black (BC) coffees on cardiovascular, anthropometrical markers and urinary free glucocor...

Seventy six-year-old man was referred to our hospital for examination of hypertension and hypokalemia. His blood pressure was uncontrolled although he was taking amlodipine besilate, spironolacton and candesartan. In addition, he suffered from atrial fibrillation and chronic heart failure. His serum potassium was low (2.8 mmol/l) and bilateral adrenal glands were found swelling. Hence, we investigated him thoroughly on the suspicion for primary aldosteronism.<p class="abst...

Nicotine (N) is known as the main toxic and addictive component of cigarette smoke. By its ability to generate reactive oxygen species (ROS) and oxidative damage in organism, it can induce major public health problems such as cancer, cardiovascular diseases and infertility. Green tea extract (GTE) is an important source of polyphenols catechins; it has attracted a great deal of attention around the world because of its potential antioxidants role in scavenging free radicals. T...

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...

Background: A major challenge in the management of breast cancer (BC) is the search for biomarkers that are sensitive and less invasive. miRNAs are reported to be tissue-specific, stable and aberrantly expressed in different tumours, hence their emerging role as potential biomarkers in BC management.Objective: The study focused on developing an in-house method for the detection of mir-145 and mir-21 using SYBR Gre...