Endocrine Abstracts

Introduction: Recent publications regarding primary aldosteronism (PA) have challenged the concept of PA being a rare disease. In 2007 a standardized protocol for diagnosing and treating PA was introduced in Iceland for patients suspected of having PA. Data from the Icelandic Heart Association suggests that 35–40% of the adult population (age 46–67) have hypertension. The aim of this study was to gather information about PA as a cause of hypertension at the referral ...

Insulinoma causes fasting hypoglycemia due to inappropriate insulin secretion. The diagnosis of insulinoma is based on Whipple’s triad (1. symptoms precipitated by fasting with 2. associated blood sugars of 50 mg/dl or less and 3. relief of symptoms by glucose administration) during a supervised 72 h fasting test. After introducing reliable assays for measurement of insulin and proinsulin, there is an ongoing debate whether a 48 h fasting test is sufficient for diagnosis ...

Background: The H-syndrome is a recently described very rare monogenic systemic autoinflammatory autosomal-recessive genodermatosis with young onset of diabetes without evidence of autoimmunity. It is caused by mutations in the SLC29A3 gene, which encodes the equilibrative nucleoside transporter hENT3.Objectives: To study the clinical features and confirm the genetic diagnosis in a subject with young onset of diabetes.Subject and m...

Background: Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) can cause long-term morbidity and death. Studies indicate that this may partially be due to transient or chronic hypopituitarism (HP). Guidelines recommend screening for HP in moderate and severe TBI patients (TBIp), Glasgow coma score (GCS) 9–12 and <9 respectively. The aim of this study was to evaluate markers of severity and physiologic changes as predictive factors for HP following TBI and ...

Objective: Acromegaly is a rare disease with multiple serious comorbidities. The aim of this study was to gather information on patients diagnosed with Acromegaly from 1955 through 2010.Materials and methods: Information on patients with pituitary adenomas diagnosed from 1950 has aldready been gathered and and imported to patient journals at the National University Hospital in Iceland. In this retrospective study information on patients diagnosed with Ac...

Introduction: Osteotropic hormones demonstrate circadian rhythms which are integral to bone homeostasis. Sclerostin is a physiological inhibitor of bone formation. We have established that Sclerostin has a distinct circadian rhythm with a nocturnal peak. Analysis was performed to determine the relationship of Sclerostin levels to PTH, Calcium, Phosphate, βCTX and P1NP in healthy young men.Methods: Six healthy young men with normal BMD were admitted ...

Introduction: Primary aldosteronism is an important cause of hypertension. Adrenal venous sampling (AVS) is the gold-standard investigation to determine whether one or both adrenal glands are affected. AVS is a complicated procedure with success rate varying greatly from one hospital to another.Aims: To investigate the success rate of AVS at Landspitali over a 10-year period and compare it to published results from other hospitals....

Introduction: Primary aldosteronism (PA) is an important, potentially curable cause of hypertension (HT) with higher risk of cardiovascular events than essential HT. In 2007, a standardized PA work-up protocol was introduced in Landspitali University Hospital (LUH), housing the only endocrine department in Iceland. The aim of this study is to review characteristics, test results and histopathology for patients diagnosed with PA in 2012-2016 in LUH.Method...

Introduction: H. pylori infection has been related with extragastric diseases such as type 2 diabetes.Aim: to evaluate changes in carbohydrate metabolism induced by 75g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori compared to healthy controls.Materials and methods: A prospective case-control study. Biochemical parameters, carbohydrate profile, ghrelin and G...

Introduction: H. pylori infection has been related with diseases such as type 2 diabetes and metabolic syndrome.Objective: To evaluate changes in carbohydrates metabolism, lipid profile and intake regulating hormones induced by 75 g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori.Materials and methods: A prospective study of 40 non-diabetics patients were perf...