Endocrine Abstracts

Aims and hypothesis: The aim of this study is to determine the baseline knowledge of diabetes and its management within two Psychiatric Crisis Resolution Teams based at NELFT NHS Foundation Trust. We hypothesise that attendance to diabetes seminars will lead to better knowledge of the condition’s management.Background: A 2014 NHS survey found that 6% of people with mental health conditions also suffered from diabete...

Aims and hypothesis: The aim of this study is to determine the baseline knowledge of diabetes and its management within two Psychiatric Crisis Resolution Teams based at NELFT NHS Foundation Trust. We hypothesise that attendance to diabetes seminars will lead to better knowledge of the condition’s management.Background: A 2014 NHS survey found that 6% of people with mental health conditions also suffered from diabete...

Introduction: Epigenetics is defined as heritable changes in gene expression without changes in the DNA sequence. The transgenerational epigenetic inheritance of diseases is an emerging area of research. Multiple environmental factors including toxicants are associated with the transgenerational inheritance of increased disease susceptibility. Endocrine-disrupting chemicals (EDCs) are a heterogeneous group of exogenous chemicals or chemical mixtures that interfere with the act...

Introduction: Obesity is a worldwide pandemic associated with increased morbidity/mortality and high cost for the society. The prevalence of obesity has doubled in more than 70 countries (including developing countries) since 1980. The number of adult subjects with obesity is around 700 million worldwide. The current pandemic in obesity cannot be explained solely by alterations in food intake and/or decrease in exercise. Obesity pandemic coincides with the marked increase of t...

IntroductionCentenarians are subjects living 100 years or older. They represent a model of successful aging. In 2020, the number of centenarians in the world was approximately 573.000. Multiple endocrine changes occur with normal aging. Most centenarians have managed to avoid, postpone, or overcome the important age-related and life-threatening diseases. The purpose of this review is to present the endocrine function in centenarians with special emphasis...

IntroductionEndocrine-disrupting chemicals (EDCs) are a heterogeneous group of exogenous chemicals or chemical mixtures that interfere with the action of hormones and cause adverse effects. Humans are constantly exposed to hundreds of EDCs mainly through air, water, and food. Pregnant women are exposed to multiple EDCs that can cross the placenta and enter the fetus. The developing fetus and neonate are more sensitive than adults to perturbation by EDCs....

Objective: Vitamin D deficiency is frequently encountered in patients with primary hyperparathyroidism (PHPT), a condition characterised by excessive parathyroid hormone (PTH) secretion and hypercalcemia. This systematic literature review and meta-analysis aimed to assess the management of vitamin D deficiency in PHPT by evaluating vitamin D supplementation regimens and their impact on vitamin D and PTH levels and calcium levels....

Introduction: Pituitary malignancies include pituitary carcinomas and pituitary metastases. These malignancies are ver, rare and create important diagnostic and therapeutic challenges. This review presents an update on pituitary malignancies.Methods: A systematic search of literature was conducted using the search terms pituitary carcinoma, pituitary metastasis, prevalence, management, and survival.Results: Pituitary carcinomas are...

Introduction: Primary hyperparathyroidism is an endocrinopathy characterized by the excessive secretion of parathyroid hormone, most commonly associated with parathyroid adenoma. The osteoarticular manifestations of hyperparathyroidism are currently exceptional. The diagnosis is most often established at the asymptomatic stage by measuring calcium levels and parathyroid hormone.Observation: We report the case of a 67-year-old patient with a history of pa...

Introduction: Individual variability in drug efficacy and safety due to genetic diversity is a major challenge for clinicians. Pharmacogenetics deals with inherited differences in the efficacy and safety responses to drugs. The incidence of type 2 diabetes (T2D) is increasing worldwide and the disease is reaching pandemic proportions. T2D is treated by oral and/or injectable drugs. The interindividual variability of T2D drug actions may be caused, at least in part, by genetic ...