Endocrine Abstracts

Objective: In acromegaly, high GH/IGF1 levels are associated with abnormal glucose metabolism. Treatment with somatostatin analogues (SSAs) reduces the GH and IFG-1 levels. However, SSAs may worsen glucose homeostasis despite this, due to concomitant inhibition of insulin secretion. We studied the possible association between biochemical cure and glucose homeostasis in de novo patients with acromegaly.Design: Post hoc analysis from a ra...

Context: Roux-en-Y Gastric bypass (RYGB) is an effective way to induce sustainable weight loss. This operation can be complicated by late dumping, also known as postgastric bypass hyperinsulinemic hypoglycemia. Much is still unknown on its prevalence and its pathophysiology.Objective: To study the prevalence and the main driving mechanisms behind the occurrence of hypoglycemia after a mixed meal tolerance test (MMTT) in patients with primary RYGB. Design...

Introduction: The endocrinologist is confronted with an increasingly large population of postbariatric patients who present with endocrine problems. One of these is early dumping, a complication that may be the result of increased entero-endocrine activity. To address the prevalence of early dumping and to gain further insight into its pathophysiology, we performed a Mixed Meal Tolerance Test (MMTT) in a random sample of patients after Roux-en-Y gastric bypass (RYGB).<p cl...

Introduction: Glucagonomas are rare functional pancreatic neuroendocrine tumours (p NETs), with an annual occurrence of 0.01 to 0.1 new cases per 100,000. Objective: We focused on presenting symptoms, primary’s size and location, presence of metastases, biomarkers at diagnosis, histology, response to first line treatment (clinical and biochemical), disease fee survival (DFS) and PFS (progression free survival). Methods: Eighteen pa...