Endocrine Abstracts

Background: Accurate intraoperative localization of primary and metastatic pancreatic neuroendocrine tumors (pNETs) is challenging, and molecularly driven fluorescence-guided surgery could significantly improve surgical outcomes with given the overexpression of somatostatin receptor subtype-2 (SSTR2). We developed an optimized SSTR2-targeted fluorescent agent, MMC(FNIR-Tag)-TOC, which expressed excellent targeting specificity and pharmacokinetics, as the lead compound for clin...

Introduction: Medullary thyroid cancer (MTC) TNM classification categorizes lymph nodes (LN) according to their location, but does not consider number and size of LN.Objective: To analyze the relationship between number and size of LN in MCT persistent disease (PD).Material and methods: Retrospective study of patients with MTC followed up in a regional hospital from 1985 to 2015. The main variables (expressed as qualitative in freq...

Background: The frequency of SH and AT in pregnancy is of the 3%, and diagnosis is determinant because of the high risk of complications (postpartum hemorrhage, abruptio placentae, gestational hypertension in the mother and disordered brain development and/or intrauterine growth retardation in the fetus).Objective: Determine the frequency of SH and AT in 300 pregnant women.Materials and methodology: About 300 pregnant women were sc...

Introduction: GH deficiency (GHD) leads to altered body composition, lipid metabolism and quality of life, and is also associated to an increased cardiovascular morbidity and mortality. The aim of this study was to evaluate long-term changes after treatment with GH replacement therapy (GHRT).Methods: We retrospectively reviewed adult patients with GHD in our clinic who were treated with GHRT. We evaluated demographic (etiology, age, dose), anthropometric...

Introduction: The incidence of papillary thyroid microcarcinomas (MPT, max diameter≤10 mm) has increased in recent years. Most have a very good prognosis but some have growth during follow-up, lymph node and / or distant metastases.Material and methods: We performed a single-center, retrospective cohort study, n=114 patients (86% women, average age 48.3 years), diagnosed with MPT between 1998 and 2012. Risk stratification system (ATA 2015): 10 high...

Corticotropinomas represent only a small fraction of all the cases of pituitary adenomas, yet they have the potential for great morbidity and mortality. Presenting clinically as Cushing’s disease (CD), corticotropinomas are characterized at the molecular level by resistance to glucocorticoid negative feedback, dysregulation of proteins controlling cell cycle progression, and overexpression of pathways that sustain overactive ACTH production and secretion. Until recently, ...

Introduction: In population, thyroid nodule incidence is 1 to 30%; malignancy incidence is 1–20% up to different series, which make us to realize diagnostic methods with variable sensibility and specificity, taking as point of reference, the cytological analysis.Materials and methods: Fifty consecutive patients (44 women, 6 men) with thyroid nodule, performed neck ultrasonography (ALOKA SSD3500 equipment); material of FNA was processed according to ...

Familial combined pituitary hormone deficiency can be due to a PROP 1 gene mutation. PROP1 is essential to pituitary morphogenesis. Mutations with inactivation of this gene results in deficiency of GH, PRL, TSH, LH, FSH and in some cases, ACTH.The authors describe an affected family, two sibs, with panhyopituitarism: a 10 years old female, and a 15 years old male, who presented with growth and pubertary development delay. Both children lacked GH, TSH, PR...

Objectives: To evaluate changes in gonadotrophins, total (TT) and free (FT) testosterone, SHBG, insulin and c-peptide levels during weight lost after bariatric surgery.Material and methods: Seven (n=7) patients submitted to bariatric surgery for treatment of severe obesity were followed-up over time. Before surgery mean age was 32,857 (19-56) years old, mean weight was 170,571 kg (± 37,362) and mean BMI was 58,824 kg per m2(± 14,...

Kallmann syndrome (KS) is characterized by hypogonadotropic hypogonadism and other non-reproductive disorders including smell deficiency due to olfactory bulb developmental abnormalities. The aim of our study was to evaluate retrospectively the role of MRI in patients with clinical diagnosis of KS, searching for any abnormalities of the brain structures involved.Methods: We evaluated 25 KS pts (14–32 years, 4F, 21 M). KS cases were classified as hyp...