Endocrine Abstracts

OBJECTIVE Induction of anaesthesia and surgical stress, factors known to trigger catecholamine release from phaeochromocytomas, are believed to result in elevated levels in the postoperative period even in the absence of such tumours, and biochemical screening is usually deferred for two or more weeks following surgery. The aim of this study was to determine patterns of peri-operative urinary catecholamine excretion in otherwise healthy subjects undergoing a single type of maj...

Introduction: We have developed a highly sensitive LC–MS assay in an attempt to improve the measurement of salivary testosterone in female samples.Methods: A 200 μl saliva sample, calibrators or QC were mixed with 10 μl working internal standard (0.1 μg/l) and 1 ml of methyl tert-butyl ether (MTBE). Vortex mixed for 4 min and frozen at −80 °C (1 h). Unfrozen organic layer was transferred to a glass tube and evaporated. The ...

A 28-year-old Asian female presented with a 2 year history of abdominal pain and bloating and irregular heavy periods. She had a normal menarche and had 3 uncomplicated pregnancies after conceiving naturally, the last 4 years before presentation. Investigations showed LH 0.7 IU/l (normal range 2-14 IU/l), FSH 8.6 IU/l (2-14 IU/l), oestradiol 2030 pmol/l (80-300 pmol/l), prolactin 346 mU/l, and normal alpha GSU (0.3mcg/l). Ultrasound scanning revealed enlarged multicystic ovari...