Endocrine Abstracts

Approximately 230 new patients with GEP-NEN are referred annually to the centre. Prevalence of GEP-NEN is increasing due to the availability of 2nd, 3rd or 4th line treatments. Oral chemotherapy is being used with increasing frequency in this setting. The NEN Team wished to explore the outcomes of patients treated with temozolomide singe agent and temozolomide/capecitabine during the previous 5 years and compare the findings with current literature. 18 patients were included i...

The Beatson West of Scotland Cancer Centre (BWoSCC) is a Regional Service for the West of Scotland and beyond. It is considered to be a Centre of Excellence in the delivery of 21st century cancer care.Whilst the role of site specific specialist nurses has been integral to many cancer teams for in excess of 20 years, this has not been the case for neuroendocrine tumours in Scotland until May 2016.An international study ca...

Explosive, multiple episodes of diarrhoea are common in patients with neuroendocrine neoplasms affecting around 30% of the patient population. This is combination with other symptoms such as red, dry flushing and wheezing constitute carcinoid syndrome. This syndrome can have a devastating effect on patients impacting upon all aspects of their being. Somatostatin analogues alone can be successful in the management of diarrhoea however in some cases this is inadequate. In 2018 T...

Pancreatic neuroendocrine tumors are rare neoplasms of this organ. The majority of them are tumors without hormonal activity. Approximately 35% of the pancreatic neuroendocrine tumors (pNETs) are functional, the most common of which is an insulinoma. We present a 57 year old lady with dyspepsia, nausea and Fe deficiency anaemia for more then a year. On examination had a epigastric mass, endoscopy was consistent with a well differentiated endocrine grade 2 tumor. Octeotide scan...

Graves' disease appears to be the clinical result of an autoimmune attack on thyroid tissue however the immune defect and triggering events remain unclear. The inflammatory process in multiple sclerosis (MS) is mediated by CD4 T lymphocytes. Campath-1H, a monoclonal antibody against the CD52 antigen of CD4 T cells, improves disease activity in MS and is associated with development of Graves' disease in one-third of patients. Thus Campath-1H provides an interesting insight into...

BACKGROUND: Dynamic function tests are needed to diagnose a range of endocrine disorders but often require in-patient investigation. A recent audit of our endocrine service revealed deficiencies that included frequent delay to investigations and cancellation of planned appointments. We developed an Endocrine Nurse Specialist (ENS) post whose role included carrying out endocrine testing in an out-patient setting to assess whether this might improve quality of care for our patie...

BACKGROUND: An audit of facilities and medical and surgical care based on the 1997 Royal College of Physicians and Society for Endocrinology guidelines for the management of pituitary tumours was carried out in the South West in 2001. We present the results for patients referred to one specialist pituitary surgeon in Plymouth.METHODS: 1. A questionnaire was sent to each endocrinology department covering staff resources, facilities for investigations and the process of care...

The transition to menopause is characterised by a decrease in circulating estradiol, relative androgen excess and a decrease in sex hormone-binding globulin concentrations. These hormonal changes are frequently accompanied by an increase in body weight, central obesity, dyslipidemia, insulin resistance and an increase in blood pressure. Aging, comorbidities, depression and inactivity further contribute to the increase in cardiovascular risk after the menopause. Beyond traditio...

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Introduction: The management of Congenital Adrenal Hyperplasia (CAH) requires specific expertise and understanding in childhood, adolescence and adulthood. Patient education and support is an integral part of this health care process, from the delivery of a diagnosis and explanation by medical staff to the more detailed education provided by nurses in order to help families understand the practical aspects of management.Background: For parents, the initi...