Endocrine Abstracts

Background: Recent studies have demonstrated antioxidant and anti-inflammatory properties of metformin and vildagliptin, that could result in some positive effects on kidney function in diabetes. Indeed, in our previous study vildagliptin attenuated routine renal dysfunction markers in insulinopenic diabetic rats, however metformin didn’t improve it. In our current study we evaluated not only glomerular dysfunction marker (albuminuria), but also novel markers of proximal ...

Non-genetic animal models of diabetic nephropathy (DN) are most commonly reproduced by using streptozotocin (STZ) which preferentially gets into β-cells via GLUT2 transporters. However, STZ administration results in nephrotoxic effects as well, due to expression of GLUT2 by renal tubular epithelial cells. We hypothesized that nicotinamide (NA), which is considered to attenuate the severity of STZ-induced β-cell damage, could also prevent tubular alteration. Starting ...

Patients with Familial Hypercholesterolaemia (FH) have premature Cardiovascular disease and have a standardised mortality ratio nine times greater than normal. FH must therefore be correctly diagnosed and treated aggressively. Referral for FH is based on fulfilling the Simon Broome’s (SB) Criteria. We aimed to evaluate practice at Queen Alexandra Hospital with regards to referral for FH genetic mutation. We set out to see whether SB’s criteria were being fulfilled wh...

Vitamin D (VitD) was shown to affect biology of vascular wall by regulating cell proliferation. However, its effects on vascular extracellular matrix (ECM) remain largely unaddressed. We investigated effects of VitD (calcitriol) on composition of ECM deposed by cultured endothelial cells (HAEC) and smooth muscle cells (HASMC) isolated from human aorta, and compared them to effects of ascorbate (VitC). Cellular monolayers were treated with or without vitamins for 72 h, then ECM...

Background: Unintented parathyroidectomy during thyroid surgery – is one of typical complications, especially when an operation is augmented by lymphodissection. In this work, we present the results of calcium metabolism analysis in such patients.Subjects and methods: 3929 operations of patients with different thyroid diseases were performed during 2010–2012 years. 82 inadvertently excised parathyroid glands were revealed at histological examin...

Background: Primary hyperparathyroidism (PHPT) associates many psychiatric symptoms and is therefore important to find out if surgery can alleviates the psychiatric symptoms and improve the quality of patient’s life.Objectives: To study the nature and severity of neuropsychiatric manifestations in patients diagnosed with hyperparathyroidism before and after surgery, as well as to evaluate the correlation of such symptoms with levels of serum calcium...

Objective: To determine the impact of combined antidepressant drugs and LT4 enhancers in treatment of patients with Major Depressive Disorder.Method: We conducted a randomized, placebo-controlled trial to determine whether LT4 supplementation had any augmentation effect on selective serotonin reuptake inhibitors (SSRIs). The study involved 70 patients with major depressive disorder; patients with hypothyroidism were excluded. Of the participants, 38 were...

Aim: To evaluate adiponectin and resistin levels and their relationship with various biochemical and metabolic and atherogenic parameters markers, as well as their correlation, and to investigate its contribution in pathogenesis of insulin resistance in cohort women with PCOS and of insulin resistance as well as in non-insulin resistant women with PCOS. Methods: This study was designed as a cross-sectional and involves 80 premenopausal women. Of these patients, 63 females have...

Introduction: Weight loss is a key initial treatment strategy in obese women with polycistic ovary syndrome (PCOS) and improves insulin sensitivity and metabolic risk factors. In some women with PCOS it may reduce hyperandrogenism and restore menstrual function, ovulation and fertility. The aim of this study was to reveal clinical predictors of menstrual response to weight loss in overweight women with PCOS.Design: overweight unovulatory women with PCOS ...

Exposure to ionising radiation, changing levels of iodine nutrition, and increased pathologic diagnosis of clinically unimportant thyroid neoplasm have all been proposed as explanations for a world-wide rise in the incidence of thyroid carcinoma over the past 6 decades. Yakutia is geographically an area of endemic iodine deficiency (the population is about 1 million). According to previous research in the endemic areas there are more occasions of follicular thyroid cancer, whe...