Endocrine Abstracts

In the current era of multi-modal imaging being performed for various pathologies, incidental non-functioning pituitary microadenomas (NFPAs) are being increasingly identified. The available literature and guidance is limited on the long-term surveillance and monitoring and hence there is a wide variation in clinical practice across the UK. We conducted a retrospective study in our institution to compare the outcome in our cohort to the current literature.<p class="abstext...

Introduction & Objective: A vital but often disregarded pillar of diabetes management is effective patient education. The objective of this survey was to identify gaps in the existing patient education resources & to understand which patient services can help boost adherence to requisite lifestyle & therapy.Methods: A cross-sectional study was conducted between January & March 2023, involving clinicians managing type 2 diabetes mellitus a...

Introduction: Central diabetes insipidus (CDI) in infants is rare and is often associated with intra-ventricular haemorrhage, congenital toxoplasmosis, intracranial tumours and anatomical abnormalities of the brain. We describe two cases of CDI associated with brain malformations, diagnosed at very young age with good response to oral DDAVP.Case 1: A 34-week IUGR girl born to consanguineous parents (first cousins) developed hypernatraemia on day three of...

Background: Type 1 diabetes (T1D) is characterised by autoimmune destruction of pancreatic beta cells leading to insulin deficiency. Prompt referral and treatment is important to prevent diabetic ketoacidosis (DKA) which remains the commonest cause of death in this condition. NICE guidance 2004, advises same day referral to specialist paediatric Diabetes team when childhood diabetes is suspected.Aim: The aim was to audit the timeliness of referrals of ch...

Introduction : Most common cause of rickets is vitamin D deficiency. Genetic mutations in the metabolism and function of Vitamin D is a rarer cause of rickets.Case report : A16 month old male presented with bilateral clavicular swelling, constipation, generalised weakness and poor growth. He also had delay in motor milestones and was only able to sit with support. He was born in the UK to consanguineous parents of Asian origin.Exam...

Background: CH has an incidence of 1 per 3500 live births per year. Early diagnosis and treatment are essential to prevent severe morbidity of mental retardation and developmental delay in children. The newborn screening programme has played a major role in management of CH.Objectives: The aim of the first audit was to identify our practice in management of CH once the newborn screening laboratory notified about an abnormal result. Following the first au...

5 α-reductase deficiency is a rare autosomal recessive condition of male psuedohermaphroditism, resulting from mutations of the type 2 isoenzyme 5 α-reductase, crucial in conversion of testosterone to dihydrotestosteroneCase report: Baby P is a full term baby, a product of a consanguineous marriage. The baby had ambigous genitalia with a clitoris, minimal glans tissue at the apex of the labial folds, gonads in the labioscrotal folds and a ureth...

Background: Neuroendocrine Tumor (NET) patients are the fastest growing population of cancer patients, hence we wanted to assess if there are gaps in patient knowledge and awareness of their disease. To improve our understanding of the factors affecting patient knowledgeability, we looked at their educational level, satisfaction with educational materials provided at initial diagnosis, other sources used for awareness, and their level of accessibility to education materials ab...

Background: Neuroendocrine tumors are a rare group of cancers. The median overall survival of these patients is ~10 years, presenting a unique issue of accrued financial distress over a long period of time. We attempted to look at the potential determinants of financial distress in NET patients, focusing on their demographics, comorbidity burden, educational status and tumor symptoms.Methods: A total of 155 patients have been enrolled in the Roswell Park...

Introduction: It is well known that struma ovarii, choriocarcinoma and follicular thyroid carcinoma can cause thyrotoxicosis. We report a rare case of a man with carcinomatosis presenting with acute thyrotoxicosis, unilateral proptosis and neck swelling.Case report: A 48-year-old man presented with a 2 weeks history of neck swelling, profuse sweating, heat intolerance, agitation, weight loss and mild unilateral proptosis. He was a smoker with a 20 years ...