Endocrine Abstracts

Background: Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis and few treatment options in advanced disease. Immune checkpoint inhibitors (ICI) have been studied in few clinical trials with a limited number of patients in ACC. No real-life data are available so far. In the present study we aimed at evaluating treatment response and safety of ICI treatment in advanced ACC and identifying clinical, biochemical, histological and molecular markers for pre...

Hemoglobin A1c (HbA1c) is used for the long-term management of patients with diabetes mellitus (DM). Hemoglobin variants other than HbA1c and e-N-lysine-glycated HbA0 may cause analytical interference in determinations of HbA1c. Hemoglobin J is an abnormal hemoglobin, an alpha globin gene variant and present in various geographic locations. Hemoglobin J (depending on its type) has different characteristics and functions. For example hemoglobin J Capetown (α2 92Gln β2...

Objective: To investigate the results of J – 131 treatments in patients (pts) with autonomous thyroid adenomas in long period of follow up.Material and Methods: We enrolled 68 consecutive pts with Plummer’s disease (50 females, 18 males, mean age 54,7 yrs, range 21 – 79 yrs) for period 2000 – 2020 yrs. 87%(59/68) pts had a unifocal nodule, while 13% (9/68) pts had multifocal toxic autonomous nodules. Pts stopped antithyroid drugs for ...

Introduction: We report the unusual case of a young patient with micturition induced headache, in which contrast-enhanced ultrasound helped to assure diagnosis of paravesical paraganglioma.Case: An 18-year-old male presented with attacks of severe headache lasting several minutes and occurring strictly after micturition. Hypertensive values up to 200/105 mmHg were detected subsequent to nearly every micturition while values before and some minutes after ...

Background: Persons with CAH may be at increased risk of developing adrenal myelolipomas, particularly if their CAH is poorly controlled. Adrenal masses can be detected by ultrasound with high sensitivity and specificity. Contrast-enhanced ultrasound (CEUS) may be a useful method in the diagnostic work-up of adrenal mass with excellent sensitivity for the diagnosis of malignancy. However, ultrasound is not included in the diagnostic algorithm of patients with CAH.<p class=...

Objective: Acoustic radiation force impulse (ARFI)-imaging is a novel ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of the present study was to evaluate the feasibility of ARFI-measurements in the thyroid tissue.Materials and methods: ARFI-imaging involves the mechanical excitation of tissue using short-duration acoustic pulses to generate localized displacements in tissue. The displacements result in...

Objective: Acoustic Radiation Force Impulse (ARFI)-Imaging is a novel ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of the present study was to evaluate ARFI for the differentiation of thyroid nodules and to compare it with the well known qualitative Realtime-Elastography (RTE)Materials and Methods: ARFI-imaging involves the mechanical excitation of tissue using short-duration acoustic pulses to gener...

Case: A 40-year-old woman presented in 04/2015 with pain in the upper abdomen and a history of paroxysmal tachycardia. Plasma normetanephrines were highly elevated. Imaging revealed a large retroperitoneal tumor (15×12×8 cm), which could be completely resected after pre-treatment with urapidil. Histology confirmed diagnosis of a paraganglioma. Genetic diagnostics detected a previously unknown mutation in intron 2 of the SDHB-gene (c.200+5G>C). Six month after ini...

Introduction: Manifestations of primary hyperparathyroidism (PHPT) such as osteoporosis and stone diseases are common primary diagnostic findings beyond a hypercalcemia. Classical skeletal involvement can be the first sign of PHPT, but not recognized because osteitis fibrosa cystica (bone cysts, brown tumors of the long bones) is rarely seen today in Western Europe.Case report: A 34-year old women from Afghanistan was presented to our out-patient-clinic ...

J J Kopchick, Ohio University, Athens, Ohio, USA. AbstractDr John J Kopchick is an internationally recognized leader in the growth hormone (GH) field. Since 1987, he has held the Milton and Lawrence H Goll Eminent Scholar Professorship in Molecular and Cellular Biology and directs the Growth/Obesity/Diabetes Section of the Edison Biotechnology Institute at Ohio University in Athens, Ohio. He also is Professor in the B...