Endocrine Abstracts

Iain Robinson, UK AbstractThis prestigious prize is intended for established workers in field of basic and clinical neuroendocrinology, and is generously supported by Ipsen. This year's recipient is Professor Iain Robinson. The prize will be presented as part of the ECE 2010 opening ceremony where Professor Robinson will deliver his lecture. Professor robinson will also deliver two other lectures at fut...

Iain CAF Robinson, National Institute for Medical Research, Mill Hill, London, UK AbstractIain Robinson was born in 1949 and educated at the King Edward VII Grammar School in Sheffield before going to Worcester College, Oxford, to study physiology and medicine. Awarded first class honours in physiology and with medical studies deferred, Iain received an MRC studentship Award for studies on endocrine physiology in the D...

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Jeffrey S Flier, Division of Endocrinology, Harvard Medical School, Boston, Massachusetts, USA Abstract Jeffrey S Flier is the George C Reisman Professor of Medicine at Harvard Medical School, and Chief Academic Officer and Harvard Faculty Dean for Academic Affairs at Beth Israel Deaconess Medical Center in Boston. Dr Flier is a graduate of the City College of New York (1968) and the Mount Sinai School of Medicine (19...

Sclerostin is an osteocyte-expressed, extracellular cystine-knot protein that is lacking in patients with sclerosteosis, a rare condition characterized by excessive bone formation. Sclerosteosis patients exhibit very high bone mass (lumbar spine Z scores up to +14) and are anecdotally resistant to bone fracture. Homozygous patients commonly develop symptoms associated with cranial nerve entrapment from excessive bone formation but do not show signs of heterotopic bone formatio...

Neuroendocrine cascades regulate essential processes in integrative physiology, such as growth and metabolism, reproduction, and responses to stress. The pioneering work of Geoffrey Harris showed that the pituitary gland, the major endocrine regulator of these processes, is itself controlled by hypothalamic neurones that secrete their products into the hypophysial portal circulation. Intermingling of pituitary cell types and the complex anatomical distribution of the different...

Pituitary growth hormone (GH) is released in a highly pulsatile fashion in response to stimuli from its hypothalamic regulators, GH releasing hormone (GHRH) and somatostatin (SRIF), as well as feedback from peripheral signals. This interplay is complex, and still poorly understood. GHRH is a major factor in controlling pituitary GH synthesis and somatotroph cell number as well as GH secretion, and lack of GHRH or its receptor cause profound somatotroph hypoplasia and dwarfism....

The neuroendocrine cascade regulating episodic growth hormone (GH) secretion plays a central role in post-natal growth and metabolism. Intermingling of GH cells with other pituitary cell types and the complex distribution of the hypothalamic GHRH neurons makes both the cell types difficult targets for selective physical or chemical manipulation. On the other hand, they are excellent targets for physiological transgenesis since their major secretory products derive from highly ...

The aim of this study was to evaluate the effects of estradiol ± different progestogens on body weight in ovariectomised mature female hooded-Lister rats.35 rats were ovariectomised under anaesthesia; following a recovery period animals were divided into 2 groups namely: (1) intermittent hormone dosing weeks 1–6 and 13–18, with no treatment weeks 7–12 and (2) delayed (no treatment in weeks 1–12) hormone treatment dosing weeks 13&...

The current PDA recommendations relating to the good metabolic control of diabetes are: self-controlled fasting blood glucose (FBG)70–90 mg%, HbA1c ≤6.1%, lipid profile (LP) TChol ≤175 mg%, LDL≤100 mg%, HDL ≥40 mg%, TG≤150 mg%.Objective: To evaluate the accomplishment of the proper metabolic control in diabetic outpatients with regard to the PDA guidelines.Material and Methods: a548 diabetics (249...