Endocrine Abstracts

A 38-year-old woman presented with symptoms suggesting Cushing’s syndrome. She has a history of surgery of mature ovarian teratoma (hysterectomy, ovarectomy) associated to radio and chemotherapy 15 years ago. The malignant teratoma relaps with hepatic and grelic metastases, and was unresectable. Main complaints were weight gain with centripetal fat distribution, muscle weakness, melanodermia and purpule striae on the skin of the abdomen, thighs, breasts and arms....

Introduction: Thiamine responsive megaloblastic anemia (TRMA) syndrome, also known Rogers syndrome is a rare autosomal recessive inherited disorder characterized by a triad features of megaloblastic anemia, sensorineural deafness and diabetes mellitus. TRMA manifestation is caused by mutations in the gene SLC19A2 encoding a high-affinity thiamine transporter, which disturbs the active thiamine uptake into cells.Case Presentation...

Introduction: GH deficiency (GHD) represents less than 20% of short stature in children, the clinical, biological and radiological characteristics differ from one population to another.Methods: Our retrospective study describe 59 children (37 boys and 22 girls) with confirmed GHD. The average age of discovery was 95 months. About 20.3% of these children were born from a consanguineous marriage. Family history of anterior pituitary insufficiency was prese...

Introduction: Insulinoma is rare tumor with an incidence of 1 in 250,000 patient-years. It presents with repeated episodes of hypoglycemia due to endogenous hyperinsulinemia, which occurs mostly in the fasting state. Insulinomas are usually sporadic, solitary, benign and encapsulated small lesions and majority of them measure <2 cm in diameter. They pose a challenge for pre-operative localization.Materials and methods: A retrospective study of patien...

Medullary thyroid cancer (MTC)is a very polymorphic tumour, it remains difficult to diagnose, especially in cytology. The MTC is characterized by a polymotphic cell population, the amyloid stroma is found in 43 to 81% of cases. In this retro and prospective study carried out over 5 years, we included 45 lesions (8 nodules, 35 lymph nodes and 2 cervical masses) these lesions were punctured and the cytological results were compared with the definitive histology. On cytology, 13 ...

Introduction: Different studies indicated the possible association between celiac disease and Helicobacter pylori (HP) infection, although this evidence is not consistently accepted. The aim of our study was to determine whether HP infection and celiac disease were associated among patients undergoing upper gastrointestinal endoscopy.Methods: Between January 2017 and June 2018, patients undergoing upper gastrointestinal endoscopy with both gastric and du...

Different studies indicated the possible association between lymphocytic gastritis and both celiac disease and Helicobacter pylori infection, although this evidence is not consistently accepted.Objective: We aimed to determine whether Helicobacter pylori infection and celiac disease were associated among patients undergoing upper gastrointestinal endoscopy.Methods: Between January 2016 and June 2017, patients over...

Introduction: Steatosis has become an important issue in hepatitis C, due to the injury it can cause in a chronically ill liver. In chronic hepatitis C patients, the prevalence of steatosis ranges from 40–86%. Steatosis was significantly associated with the lack of response using PEG-IFN and ribavirin. The aim of our study was to determine the prevalence of hepatic steatosis in chronic hepatitis C and determine its impact on the therapeutic response using new direct antiv...

Medullary thyroid carcinoma (MTC) is a rare but relatively serious disease, whose prognosis depends on the stage of the tumor and the quality of the initial surgical treatment. The determination of the plasma calcitonin; cervical ultrasound, and fine needle aspiration biopsy are first line examinations; nevertheless they do not always make it possible to make a certain diagnosis in preoperative; moreover they do not define the MTC nodule in a multi nodular goiter and the metas...

Introduction: Klinefelter syndrome is a genetic condition that results when a boy is born with an extra copy of the X chromosome. Klinefelter syndrome is a genetic condition affecting males, and it often isn’t diagnosed until adulthood. It is manifested by gynecomastia, small testicles, erectile dysfunction, infirtility …Observation: 70-year-old male patient with motor and cerebral infirmity, several fractures following minimal trauma. Hospita...