Endocrine Abstracts

Introduction: Hypothalamic-pituitary-adrenal axis dysfunction (HPA) has been reported in patients with schizophrenia and bipolar disorders but findings are inconsistent and few studies have conducted direct comparaisons of HPA biomarkers in drug native patients. We aimed to assess serum and salivary cortisol in the morning in drug-naive schizophrenic patients compared to controls.Methods: This was a cross-sectional case-control study conducted between Ju...

It is well established that sex steroid deficiency induces bone loss, resulting in osteoporosis. Consequently, global androgen receptor knock out (ARKO) mice have trabecular and cortical osteopenia. Bone cell-specific ARKOs however, have a much less pronounced bone phenotype, suggesting that androgens have an influence on processes in other systems or organs which in turn have an impact on bone metabolism. The kidney is a likely candidate, as it plays an important role in calc...

Introduction: The obstructive sleep apnea syndrome (OSAS) has a well-documented association with increase cardiovascular morbidity and mortality. The patients with OSAS have a high prevalence of hypertension (HTA).Case report: A 52-year-old female with a history of poorly controlled resistant HTA was admitted to our hospital with severe HTA. She had a history of fatigue and intermittent episodes of palpitations. Laboratory evaluation was significant for ...

Objective: To determine the relationship between metabolic syndrome (MS) and cognitive decline in type 2 diabetes patients over 65 years age.Methods: The age of the participants were between 60 and 87 years old. According to NCEP ATP III criteria 30 had MS and 28 had not. Cognitive performance was determined with the use of standardised mini mental test and the mini mental scores (MMS) of the two groups were compared. Apart from the MS we investigated th...

Introduction: Empty sella in male patients is a very rare situation. It could be diagnosis in acquired male hypogonadotropic hypogonadism or hypopituitarism.Case report: A 55-year-old type 2 diabetes male was referred to our hospital with erectile dysfunction (ED). He has three children. His secondary sex characteristics, sexual function, and ejaculation were previously normal but for the last 3 years he had ED. His genital stage was Tanner V, and pubic ...

Introduction: Hyperthyroidism produce changes in cardiac contractility, blood pressure, and systemic or pulmonary vascular resistance. In almost all cases these cardiovascular changes are reversible when the underlying thyroid disorder is recognised and treated. Pulmonary hypertension (PAH) has been associated with thyroid dysfunction, but primarily with hyperthyroidism. The vast majority of patients with this form of PAH are usually older with toxic multinodular goitre. The a...

Introduction: A 66-year-old woman was admitted as an emergency with vomiting, hypotension and serum cortisol of 0.92 microg/dl indicative of adrenal failure. She was found to be hyperthyroid (fT4=72 pmol/l).Case report: She had hypotension (blood pressure 80/40 mm/Hg) She was fit and well till the age of 65. Endocrine assessment revealed deficiency in ACTH-cortisol, growth hormone, and gonadotropin, as well as low-normal fT4. On the...

Introduction: Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the foetus.Case presentation: We report a case of hyperthyroidism in a 28-year-old woman that occurred at 20 weeks gestation. This situation was due to Graves’ disease. Propylthiouraci...

Introduction: Fahr’s syndrome and primary hypoparathyroidism are two rare diseases. Fahr’s syndrome is characterized by abnormal calcified deposits in basal ganglia and cerebral cortex and by the classic association with hypoparathyroidism. We report two cases of Fahr syndrome revealing an unknown primary hypoparathyroidism.Observation 1: A 36 year-old man, with a history of schizophrenia and generalized tonic-clonic seizures since two years. H...

Introduction: Association between primary hyperparathyroidism and nodular thyroid disease is well recognized, this is mainly due to the high prevalence of this disease. However, association between thyroid carcinoma and primary hyperparathyroidism is less common.Observation: Fifty-two years old patient with a history of renal colic and upper limb spontaneous fracture was followed for multinodular goiter evolving for 20 y...