Endocrine Abstracts

Introduction: Thyroid nodule is a common disease that is found in 50% of the adult population; of total, 5% of thyroid nodule cases are diagnosed as thyroid cancers. Thyroid ultrasonography is the most sensitive diagnostic imaging method for the diagnosis of thyroid cancer. The ultrasonographic findings that indicate malignancy are taller than wider, speculate margins, marked hypoechoic lesion, microcalcification, and macrocalcification. In contrast to findings indicating pure...

Growth hormone (GH) therapy (GHT) requires long-term commitment to daily sc GH injections that may present adherence challenges. Patient preference and adherence have been shown to be affected by delivery devices in association with convenience of administration, level of injection-site pain, confidence in correct dose administration and satisfaction with the device. This survey investigated if switching GH device – from NordiLet/others to NordiFlex – improved pati...

Purpose: Telomerase reverse transcriptase (TERT) promoter mutations are associated with tumor aggressiveness. The purpose of our study was to demonstrate the ultrasonographic (US) features of TERT promoter-mutated follicular thyroid cancer (FTC) and to evaluate their predictive performances.Materials and methods: Total 63 patients who had surgically confirmed FTC between August 1995 and April 2021 were included in this study. All of them were available f...

Background: The purpose of this study was to assess the role of ultrasound (US) in predicting tumor invasiveness in follicular thyroid carcinoma (FTC) based on the World Health Organization (WHO) classification and telomerase reverse transcriptase (TERT) promoter mutation.Materials and Methods: This retrospective study included 54 surgically confirmed FTC patients who underwent preoperative US and TERT mutation analysis. The WHO classification consisted ...

Background: Some regrowing nodules after radiofrequency ablation (RFA) of symptomatic large benign thyroid nodules are revealed as malignancies in surgery. The aim of the study was to assess the ultrasound (US) characteristic of thyroid nodules diagnosed as cancer later, the predictive factors for cancer after RFA, and the prevention methods for these cancers to avoid RFA.Materials and Methods: The medical records of 22 thyroid nodules with 18 patients w...

Introduction: Elevated parathyroid hormone (PTH) levels are associated with increased cardiovascular diseases (CVD) in the patients with impaired kidney function. We aimed to investigate whether PTH levels are associated with CVD in persons without significant renal diseases.Methods: This is a cross-sectional study and we included 1951 Korean subjects aged ≥30 years (men 46.6%), who underwent 64-slice multidetector-row cardiac computed tomography (...

Introduction: Intensive insulin treatment regimens, multiple daily injections (MDI) and continuous subcutaneous insulin infusions (CSII) are used widely in the NHS, despite a lack of evidence that more expensive treatment with CSII is superior to MDI. In this presentation, data from previous observational and interventional studies will be reviewed. The findings of the SCIPI study (SubCuntaneous Insulin: Pumps or Injections?), which compared the effectiveness, safety, quality ...

AMEND provides information resources and support services to families with MEN syndromes, offering free membership, educational and peer support events, and a free Counselling Service provided by rare disease specialist psychotherapy organisation, Rareminds. Our 2021 Counselling Service feedback data (n=24) showed that the biggest issue by far for patients is dealing with their diagnosis (39% of respondents). Managing symptoms and treatment are also significant issues...

Background: Active surveillance (AS) has been widely accepted as a safe option in the treatment of low risk papillary thyroid microcarcinoma (PTMC) in recent years on the basis that its prognosis is not inferior to immediate surgery. However, clinicians as well as patients are still hesitant in actually choosing AS over immediate OP as treatment. Our aim was to investigate the factors in choosing treatment options in low risk PTMC.Method: Seoul National ...

The DPP4 inhibitors that increase insulin secretion by glucose dependently can also relieve insulin resistance because they improve early phage insulin secretion and prevent late hyperinsulinaemia. It also can be more effective in controlling the blood glucose because it acts synergistically with metformin by improving insulin secretory dysfunction compared TZD with metformin that has similar action mechanism. One of those is gemigliptin that was developed in this country rece...