Endocrine Abstracts

Primary aldosteronism (PHA) is one of the most common cause of secondary hypertension. It can possibly concern over 10% of hypertensive patients, but often is being under-recognised. The basic tool of case PHA detection is aldosterone to renin ratio (ARR). Appropriate cutoff value of ARR is still under discussion.We review occurrence of CT/MRI detectable adrenal gland laesions according to assigned ARR cutoff value. Retrospective data from 833 consecutiv...

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of hypertension concerning about 5–12% of hypertensive individuals. Aldosterone to renin ratio (ARR) and 24 h urine aldosterone concentration (24-UAC) are important tools in PHA screening diagnostics. The most appropriate cutt off values predicting PHA are still being discussed. The study is to assess siutability and to determine optimal cut off values of ARR and 24-UAC for accurate PHA pred...

Laparoscopic surgery of adrenal tumours is widely used because of its high effectiveness, patients safety and relatively low cost. Current indications to adrenalectomy of oncological and endocrinological origin are highly accepted. However there is still lack of perfect clinical tool identifying malignant lesions. In everyday practice clinicians rely on low specific features, especially considering larger nonsecretory lesions to surgery.To show the lands...

Introduction: Primary hyperaldosteronism (PHA) is the most common hormonal cause of secondary hypertensionconnected with substantially higher cardiovascular morbidity and mortality than essential hypertension (EH). The association between aldosterone excess in PHA and mutations in KCNJ5 and CACNA1D genes has been previously described and the possible relation with gene polymorphisms was to consider. The present study is to assess possible association between polymorphisms of i...

Introduction: The GEP NEN (gastroentero-pancreatic neuroendocrine neoplasms) are 70% of all neuroendocrine tumors, but are rare in general population – constituting only 2% of the gastrointestinal tract neoplasms. Carcinoid stands for 50% of GEP NEN, most often located in the appendix and/or ileum. Although the detection of NEN is rising, their prevalence is still likely underestimated. The clinical presentation is not characteristic at the early stages of the disease, it...

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder. Beside renal and skeletal complications, it has a wide variety of nonspecific symptoms from other organs that may mimic other diseases and delay the diagnosis. Nowadays PHPT evolves to less-symptomatic.Aim: The aim is to revise symptomatology profile of PHPT in a single region of Poland; and to help early PHPT diagnosis – encouraging interdisciplinary contact between me...

Anna Spada is currently Full Professor at the School of Medice, University of Milan. Her main research interests are on signal transduction in pituitary cells, pathogenesis of pituitary tumors, genotype/phenotype relationships in acromegalic patients with gsp mutations, tissue specific GNAS1 gene imprinting, molecular mechanisms of resistance to hormone action, activating and inactivating mutations of GNAS1 in endocrine disorders, polymorphic variants of somatostatin receptor ...

A 65-year-old gentleman was referred by his GP because of acute kidney injury and hypercalcaemia, which was associated with low levels of parathyroid hormone. He had been fit and well and was on no regular medications. Whilst his hypercalcaemia was partly correctible with saline rehydration, cautious use of bisphosphonates and cinacalcet were not effective in preventing rebound, and his nephropathy persisted. Curiously, he had longstanding low plasma alkaline phosphatase, but had normal denti...

Context: Both polycystic ovary syndrome (PCOS) and chronic autoimmune thyroiditis (AIT, Hashimoto disease) are common endocrinopathies and the AIT is the most prevalent cause of hypothyroidism in areas with sufficient iodine intake. Patients with PCOS are probably more susceptible to the development of autoimmune diseases. The data about the prevalence of AIT in PCOS is limited and it has not been assessed in the Polish population.The aims of the study w...

Background: Radioiodine is an effective treatment for Graves’ hyperthyroidism. In most cases this therapy renders the patient completely hypothyroid. As a consequence they will require lifelong thyroid replacement therapy. Now it is controversial whether radioiodine should be given in a sufficient dose to induce hypothyroidism or a lower dose in an attempt to achieve a euthyroid state. Case Report: A 71-year-old woman with a 30 years history of Grav...