Endocrine Abstracts

Background: Primary hyperparathyroidism (pHPT) is a common disease in a routine endocrinology praxis, but the biggest challenge is a localization of the adenoma and the further correct management of the disease. First FCPCT was reported in 2014 as the additional method of diagnosis of pHPT and in some centers has been already used as a first line diagnostic modality. However, FCPCT is still lacking in the European or International guidelines for the diagnosis of pHPT.<p cl...

Background: Social deprivation is high within our large ethnic and diabetes prevalent population. Compliance is a major stumbling block in the achievement of Blood Pressure (BP) targets. Given the above, we took the opportunity to enrol with West Midlands Academic Health Science Network (WMAHSN) Florence (Flo) Exemplar project mobile phone texting service. Flo sends advice and collects patient information which clinicians can access through any device connected to the internet...

Achieving pregnancy through in vitro fertilization requires a minimum number of oocytes recovered during egg retrieval. These oocytes come from ovarian hyperstimulation that allows the entire oocyte cohort to mature. In physiology in a natural cycle, a dozen follicles are recruited at the beginning of the menstrual cycle under the action of the elevation of the FSH (the « FSH window »). Then, follicles secrete estradiol through aromatase under the action of FSH. By n...

Loss of gonadotropin-releasing hormone (GnRH) and cognitive deficits have recently been demonstrated by our group in conditions including Down syndrome and Alzhiemer’s disease. In some patients with COVID-19, olfactory and cognitive alterations persist, and persistent hypotestosteronemia in SARS-CoV-2-infected men could be a consequence of deficient GnRH. To understand whether neuroinvasion of GnRH system by SARS-CoV-2 could explain some post-COVID symptoms and thus resul...

Background: The prevalence of the metabolic syndrome (MS) is notably higher in patients with PCOS than in the general population. Presumably, this prevalence increases as a function of age but the subgroups of patients less than 20 yr. old studied so far are small.Design: In order to further document this issue, we have selected for this study 498 patients with PCOS aged 12.5–38 yr (Rotterdam definition) and 188 control women aged 15.5–38.5 yr,...

Peroxisome proliferator-activated receptor-gamma (PPARgamma) is one of the isoforms of the PPAR-family of nuclear hormone receptors. Ligand activated PPARs dimerise with retinoid X receptor and act as transcription factors translating nutritional, pharmacological and metabolic stimuli into changes in the expression of genes. PPARgamma is thought to serve several roles in adipocyte differentiation, fatty acid and lipid metabolism and insulin sensitivity. PPARgamma has also been...

Hyperthyroidism in Graves’ disease (GD) is caused by thyroid-stimulating autoantibodies to the TSH receptor. Hypothyroidism in Hashimoto’s thyroiditis (HT) is associated with thyroid peroxidase and thyroglobulin autoantibodies. Transformation of HT to GD has been rarely reported. We report a woman with history of HT, who then developed GD.Case presentation: A 50-year-old female with a past history of hypothyroidism due to HT treated with Levo...

Objective: To emphasize the difficulties to distinguish between uterine agenesis and extreme uterine hypotrophy in the context of primary amenorrhea with delayed puberty.Patients and methods: Among adolescents who consulted our center because of primary amenorrhea, from 1997 to 2005, three patients were referred for a suspicion of Mayer-Rokitansky-Kuster-Hauser Syndrome, after ultrasonography had failed visualizing the uterus. The 3 patients underwent en...

Background: Multiple unmet needs of patients diagnosed with a neuroendocrine tumor (NET) have been described in the literature, especially informational and psychological needs. A multidisciplinary approach has been suggested to improve overall care of NET patients. Trained patient advisors (PA) could complement the healthcare team, by providing a personalized accompaniment to patients based on their experiential knowledge, therefore helping to bridge this current gap. The aim...

Hyperthyroidism is rarely associated with malignancy. Some cases of co-existing between hyperthyroidism and thyroid carcinoma have been described. We report a case of association of a toxic thyroid nodule and papillary microcarcinoma.Observation: A 50-year-old male was referred to the endocrinologist for hyperthyroidism (TSH: 0.01 mUI/l, FT4: 22.8 pmol/l, FT3: 17.1 pmol/l). Thyroid ultrasonography showed a nodule of 38 mm in the left lobe. 99 mTc thyroid...