Endocrine Abstracts

Introduction: Ectopic parathyroid adenomas are detected 16% of patients operated for primary hyperparathyroidism and 22% of them may be located in the anterosuperior mediastinal region. Herein we present a rare case of primary hyperparathyroidism with severe long-term elevated parathormone (PTH) levels due to ectopic parathyroid adenoma in mediastinal region that was successfully treated by using video-assisted thoracic surgery (VATS).Case report: A 38-y...

Introduction: Primary pituitary sarcoma causally unrelated to radiotherapy, but an increased risk of second brain tumors continues beyond 20 and 30 year after treatment.We report an acromegalic patient with intrasellar giant adenoma invased suprasellar and nasal cavity during follow-up after radiotherapy.Case: A 39-year-old woman had transsphenoidal and transcranial operation in 2002 and 2003 respectively. She had also conventional...

Androgen receptor (AR) signaling is critical at all stages of prostate cancer including chemically castrated late-stage forms of the disease. How the AR can initiate transcription in the absence of androgens has been proposed to occur through several mechanisms including the production of constitutively active androgen receptor variants. Lacking a ligand binding domain, these variants are intrinsically resistant to all clinically approved AR antagonists and have been found to ...

Family history of thyroid disease (Karger 2010) and family history of goiter (Singer 2011, Knudsen 2003, Gebremichael 2020) were found to be associated with risk of goiter though some did not observe this association (Phitayakorn 2006). On participants of the Isparta Menopause and Health (IMH) Study, we measured TSH (n=1099) and thyroid sonographic parameters (n=994) including TV, thyroid nodularity (TN) and heterogeneity (TH). Health related factors and hist...

Background: Immune function and responses are tightly regulated by the circadian clock system and hypothalamic-pituitary-adrenal (HPA) axis. Accumulating evidence supports that there is a strong mutual relationship between these two regulatory systems at multiple levels. Recent publications suggest that the clock system may also regulate glucocorticoid release from adrenal glands by altering the sensitivity of the adrenal cortex to adrenocorticotropic hormone (ACTH).<p cla...

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

Introduction: Schwannomas are benign, encapsulated, solitary, slow-growing tumors which originate from nerve sheath cells in cranial, periferic, symphathetic nerve system. Aproximately, 25–45% of schwannomas are in head and neck region. N. Vagus Schwannoma are seen relatively, rarely. The patients frequently apply with a slow-growing, painless servical mass. Malign transformation is unusual.Case report: The patient 37 years old applied to our clinic...

Introduction: Although dipeptidyl peptidase-4 (DPP-4) inhibitores are generally safe and are associated with less side effects compared to other oral antidiabetic medications, they could also be associated with some side effects including skin rash. Herein we report the first case of a type 2 diabetes patient who developed a painfull maculopapular rash induced by linagliptin, a widely used DPP-4 inhibitor.Case presentation: A-54-year old female patient w...

Irisin is a myokine induced by exercise, that converts white fat tissue to brown fat tissue, thereby increasing thermogenesis and providing energy expenditure. The aim of this study is to determine the relationships between serum irisin levels and glucose and lipid parameters in obese children with and without non-alcoholic fatty liver disease (NAFLD). A total of 60 pubertal obese children (31 F, 29 M, age range: 11–18 yrs.) were included in this study. 30 of Whom had NAF...

Background: Obesity is one of the most critical problems nowadays, its frequency and consequences. Since the risk of morbidity and mortality increases in obese individuals, lifestyle changes, pharmacotherapy, and bariatric surgery (BS) methods are used for treatment. BS is generally considered the most effective method to treat morbid obesity. However, it is known that thyroid function has a role in weight regulation, the effect of preoperative thyroid function on weight loss ...