Endocrine Abstracts

Background: The highest rates of childhood obesity are among children from lower socioeconomic groups. Tier 3 weight management services for children currently rely on an MDT approach that is focused on the management of complications associated with excessive weight, but the resources are generally limited. Evidence suggests that the input in the community is key to empower children, young people, and their families to make healthy lifestyle changes, although the availability...

Steroid receptors (SR) respond to binding of their ligands with rapid signal transduction resulting from engaging extra-nuclear receptors. This occurs in addition to the conventional aspects of steroids/nuclear SR that regulate gene transcription. In breast cancer, estrogen and progesterone receptors (ER, PR) are present at the plasma membrane in addition to the nucleus. Here the receptors activate many pathways as G-protein coupled receptors, resulting in epigenetic and genet...

Steroid receptors (SR) respond to binding of their ligands with rapid signal transduction resulting from engaging extra-nuclear receptors. This occurs in addition to the conventional aspects of steroids/nuclear SR that regulate gene transcription. In breast cancer, estrogen and progesterone receptors (ER, PR) are present at the plasma membrane in addition to the nucleus. Here the receptors activate many pathways as G-protein coupled receptors, resulting in epigenetic and genet...

Background: An association between breast cancer (BC) and thyroid autoimmunity has been frequently observed, and several small-scale studies correlated the presence of autoantibodies to thyroid peroxidase (TPOAb) with an improved BC outcome. We aimed to clarify in a large cohort of patients whether circulating TPOAb are prognostic for BC recurrence.Materials and methods: Available plasma samples for patients with node-positive or high-risk node-negative ...

This presentation will describe the barriers, the business case and the benefits of employing returners to science, engineering and technology (SET) careers by the only organisation in the UK solely dedicated to returning scientists to careers. The Daphne Jackson Trust is an organisation that offers Fellowships to men and women who have taken a career break from science, engineering or technology. With falling numbers of graduates entering SET careers, employers in both academ...

The adrenal cortex functions to produce steroid hormones that are essential for life and regulate key biological processes, such as control of blood pressure, metabolism, reproduction, stress, and the immune response. In order to achieve both a rapid and precise response, the adrenal cortex employs hormonal feedforward-feedback systems that function in the context of histologically distinct adrenocortical zones. These layers, the outer zona glomerulosa (zG), intermediate zona ...

Neuroendocrine cancers represent the tenth most prevalent type of cancer in England. However, people with neuroendocrine cancer currently face significant inequities throughout the entire care pathway – from suspected cancer to follow-up care. Despite expert clinical guidelines, there is no currently available national Neuroendocrine Cancer Patient Referral and Care Pathway. Guiding principles of optimal patient pathways include the promotion of earlier, accurate diagnosi...

Explosive, multiple episodes of diarrhoea are common in patients with neuroendocrine neoplasms affecting around 30% of the patient population. This is combination with other symptoms such as red, dry flushing and wheezing constitute carcinoid syndrome. This syndrome can have a devastating effect on patients impacting upon all aspects of their being. Somatostatin analogues alone can be successful in the management of diarrhoea however in some cases this is inadequate. In 2018 T...

A 42 year old female presented with classical symptoms of hypothyroidism. Thyroid function tests confirmed hypothyroidism: TSH >100 mu/L and free T4 7 pmol/L. Thyroid peroxidase antibodies were significantly elevated at >3340 iu/ml. She was started on thyroxine 150 mcg but 3 months later the TSH remained elevated at 45 mu/L. Further review indicated no significant symptomatic improvement and TSH remained high at 61 mu/L. Her thyroxine dose was increased to 200 mcg but ...

Case History: A 57 year old male, who was known to have primary hyperparathyroidism was admitted to hospital due to hypercalcaemia on routine blood tests (adjusted S. calcium- 3.44 mmol/l.) He had no symptoms due to hypercalcaemia. This was his 5th admission since the diagnosis 18 months ago, each admission requiring treatment with IV fluids and IV bisphosphonates. SESTAMIBI and ultrasound scans of the thyroid and parathyroids had previously localised a likely right inferior p...