Endocrine Abstracts

Background: Success of Graves’ orbitopathy (GO) immunosuppression treatment is highly variable; patients relapse and a debilitating residual disease burden often remains with current therapies. This study describes the outcomes of immunosuppression in a multi-ethnic GO cohort treated in accordance with pre-2021 European Group on GO (EUGOGO) guidelines with first-line intravenous-methylprednisolone (IVMP). This study aims: (1) To evaluate the effect of first-line and addit...

Background: Ischemic stroke is an unusual but important complication of Graves’ Thyrotoxicosis that is induced by the hypoercoaguable state of thyrotoxicosis.We present a 24-year old female patient admitted with a 3-day history of intermittent slurred speech associated with numbness of the right side of her mouth and face preceded by left sided headache.She had a history of uncontrolled Graves’ disease secon...

Background: Ischemic stroke is an unusual but important complication of Graves’ Thyrotoxicosis that is induced by the hypoercoaguable state of thyrotoxicosis.We present a 24-year old female patient admitted with a 3-day history of intermittent slurred speech associated with numbness of the right side of her mouth and face preceded by left sided headache.She had a history of uncontrolled Graves’ disease secon...

Successful embryo implantation requires changes in endometrial gene expression of biomarkers which contribute to uterine receptivity to facilitate blastocyst attachment. Osteopontin (OPN), expressed at the maternal–foetal interface may facilitate implantation in processes, such as cell adhesion, migration and angiogenesis which require OPN signalling via CD44 and integrin receptors. As coordinate expression of OPN and receptors is shown to be cycle-dependent and up-regula...

At implantation, the ability of an embryo to successfully attach to the luminal epithelium is dependent on the receptive phenotype the endometrium must acquire. This spatially and temporally restricted period of uterine receptivity is defined by endometrial molecular adaptations, highly regulated by embryonic-derived signals and ovarian steroids. Critical to this isthe expression of adhesivemoleculesintegrins and osteopontin (OPN) at the foetal-maternal interface which facilit...

Hypoglycaemia is one of the most common biochemical abnormalities observed in the neonatal, infancy and childhood periods. Despite the commonality there is still confusion about the definition and management of hypoglycaemia. Hypoglycaemia can be due to many causes (including endocrine and metabolic) in the neonatal, infancy and childhood period. For example hyperinsulinaemic hypoglycaemia is the most severe form of hypoglycaemia in the neonatal period whereas ‘ketotic&#1...

Hyperinsulinaemic hypoglycaemia (HH) is a cause of severe and persistent hypoglycaemia in the newborn period. It is an extremely heterogeneous disorder with respect to clinical presentation, pancreatic histology and molecular biology. The clinical severity of HH varies mainly with age at onset of hypoglycemia (severe hypoglycemia in neonates) and has major consequences in terms of therapeutic outcome and genetic counseling. The commonest genetic cause of persistent HH are auto...

Hyperinsulinism causes recurrent and severe hypoglycaemia in the newborn, infancy and childhood period. Although the condition is more common in the newborn period it can present even adults can present with late onset hyperinsulinaemic hypoglycaemia not due to an insulinoma (noninsulinoma pancreatogenous hypoglycemia). Hyperinsulinaemic hypoglycaemia encompasses a heterogeneous group of disorders with respect to clinical presentation, pancreatic histology and molecular biolog...

Background: Cardiovascular disease (CVD) is a leading cause of mortality. Childhood obesity is a major contributor to CVD. Atherogenic index of plasma (AIP) is an indicator of risk of atherosclerotic CVD. Associations between childhood obesity and CVD risk in the region remains under-explored. We aim to investigate this association as a predictor of CVD in this young population.Methods: Patients who attended our Centre (2009-2019), age ≤19 years an...

Background: The obesity prevalence surge in children and adolescents is associated with dysglycaemia, dyslipidaemia and long-term cardiovascular complications. Use of lipid-lowering medications1 has been recommended following lifestyle modifications. We aim to investigate the demographic, and changes in LDL-c, in these young patients, in the presence and absence of dysglycaemia.Methods: Complete lipid profiles of patients (≤19 years old)...