Endocrine Abstracts

Adipose tissue is central to the control of energy and glucose homeostasis. Modulation of corticosteroid action in adipose tissue represents a potent mechanism to alter this homeostasis. Corticosteroid hormone action in adipocytes has long been considered to be mediated by glucocorticoid receptors (GR). We and others have recently identified the mineralocorticoid receptor (MR) as a new target to modulate adipocyte function. The generation of homo- and heterodimers of the GR an...

Vasotocin (AVT), the avian homolog of vasopressin, is synthesized in the BSTM of chickens in addition to the hypothalamo hypophysial axis. In previous reports, sex specific AVT–immunoreactivity(ir) in male BSTM (Jurkevich et al. 1999) and it’s ontogeny were demonstrated (Grossmann et al. 2002). In addition, galanin (Gal) was found in male BSTM co-localized to AVT. In the present study, the ontogeny of AVT- and Gal-ir was investigated in the SON as part ...

Brown adipose tissue (BAT) is key in energy homeostasis. Catecholamines are critically involved in the regulation of BAT-thermogenesis, yet current research has focussed on noradrenaline and adrenaline. Some evidence suggests a role of dopamine (DA) in BAT-thermogenesis but the intracellular mechanisms have not been addressed. We applied our extensively characterised murine brown adipocyte cell line to address these questions.D1-like and D2-like receptor...

Background: TSH-suppressive therapy in patients with differentiated thyroid carcinoma (DTC) leads to iatrogenic thyrotoxicosis and may be associated with alterations in body composition and bone mineral density (BMD). Its effects on a sarcopenia in elderly have not been in detail investigated.Objective: The objective was to compare changes in total and areal lean body mass (LBM), body fat mass (BFM) and BMD in postmenopausal female patients with DTC duri...

Purpose: To determine the risk of developing hypopituitarism after cranial irradiation for skull base meningiomas. Cranial irradiation is often chosen as first treatment in skull base meningiomas to avoid risk to proximally-located critical structures. While cranial irradiation has been associated with high risk of inducing hypopituitarism, few studies concern meningiomas.Methods and materials: Fifty-two adult patients receiving photon-beam therapyfor sk...

Erythropoietin (EPO) is an oxygen-regulated hormone promoting the differentiation of erythroid progenitor cells. Apart from hypoxia, few data is available about EPO release by secretagogues including hormones. This retrospective study evaluated serum EPO concentrations in serum leftovers from subjects routinely investigated with various endocrine disorders displaying: peripheral hypothyroidism or hyperthyroidism, acromegaly, endogenous Cushing’s syndrome or non secreting ...

Background: Both Transoral (TOETVA) and several Retroauricular approaches (e.g. EndoCATS) are described as feasible and safe procedures in the literature. The TOETVA enables angulation of instruments and provides a good working space by dividing the strap muscles in the first step. Therefor one should be able to dissect even larger specimen than the short incision in the lip allows to remove. However EndoCATS is a single port access with limited working space, but with good po...

BackgroundOnly limited data are available regarding adverse effects of gender affirming hormonal treatment (HT) mainly due to the lack of population-based studies with adequate controls, thus making spontaneous reporting systems a valuable tool to detect potential side reactions.ObjectiveIn this nationwide retrospective study, we aimed to analyse adverse drug reactions (ADRs) in relation to gender affirming H...

Background: During the last decennium, an increase in the number of persons referred to gender identity centres has been observed. Epidemiological data have not yet been formally studied in France. Here we report the experience from the Trans’Est Gender Identity Centre of the University Hospital of Nancy.Aim: To study the number of people seeking transgender care, the age at referral and the trends in the sex ratio.Methods: Th...

Introduction: Appendiceal neuroendocrine neoplasms (ANEN) account for approximately 50% of all primary tumors of the appendix and are between the first and third-most frequent gastrointestinal neuroendocrine neoplasms. Data regarding trends in incidence, management and prognosis of ANEN is limited.Aims: To evaluate temporal trends in ANEN incidence, evaluation and management over a 13-year period.Materials and methods: Appendectomy...