Endocrine Abstracts

Introduction: According to the literature, the CRH test has the highest specificity in excluding ECS (ACTH 93.9%, cortisol 89.4%). A combination of the high dose dexamethasone test (HDDST) and CRH/desmopressin test (CRH/desmopressinT) is used to increase the discriminatory capacity in ACTH-dependent CS.Objectives: This study aims to investigate the response to dynamic tests in ECS patients.Methods: 35 consecutive ECS patients were ...

Pasireotide is a a synthetic polypeptide second-generation somatostatin analogue that can be used in the treatment of GH- and ACTH- secreting pituitary neuroendocrine tumors (PitNETs), however, there are single reports of pasireotide treatment in other subtype of PitNETs. We present a case series of aggressive, giant PitNETs treated with pasireotide alone or as multimodal therapy.Case 1: A 33-year-old male reported to the Clinic due to severe headaches a...

Introduction: The data on giant prolactinomas (the rare (3%) subtype of lactotroph PitNET (≥40 mm) ), often causing clinical and therapeutic difficulties are scarce.Aim: We studied clinical/biochemical and treatment outcomes differences between giant and macroprolactinomas.Materials and methods: Consecutive patients with giant prolactinomas ≥40 mm (GP) and macroprolactinomas >10 mm<40 mm (MP) treated in the tert...

Introduction: Ectopic Cushing’s syndrome (ECS) is a rare disease with limited and error-prone published data on the epidemiology, clinical presentation and diagnosis of ECS.Objectives: This study aims to examine the clinical course of patients with ECS in relation to the primary tumor localization.Methods: Thirty-five consecutive ECS patients at a tertiary clinical center were analyzed. The clinical, biochemical (including CRH...

Thyrotropinoma is a very rare cause of hyperthyroidism. In October 2014 a 41-year-old male patient was examined for anaemia and diarrhoea. Abdomen CT scan, gastroscopy, colonoscopy and parasite tests did not reveal any abnormalities. The patient had lost 18 kg 7 years ago and his weight had been stable since then (BMI 21.3 kg/m2). The laboratory tests revealed high TSH, normal fT4 and low cortisol level. The patient referred to our department presented wi...

Background: O-6-Methylguanine-DNA-methyltransferase (MGMT) is a DNA repair enzyme. It has been demonstrated that its higher expression counteracts cytotoxicity of alkylating agents used in the treatment of glioblastoma or invasive pituitary tumors. Little is known on the relationships between MGMT expression and invasiveness of corticotroph adenomas in Cushing disease (CD).The Aim: To evaluate MGMT expression and its associations with clinical, neuropath...

Introduction: Cardiac disease called acromegalic cardiomyopathy may be present in patients with acromegaly at diagnosis, however most echocardiographic studies showed that systolic function in these patients is normal. Speckle tracking echocardiography (STE) is a novel method that allows for the study of global longitudinal strain (GLS), a marker of early and subclinical left ventricular (LV) systolic dysfunction.Objective: To evaluate left ventricular G...

Background and aims: Current glycaemic treatment targets for women with gestational diabetes (GDM) are controversial. The aim of the study was to compare the effect of different intensities of glycaemic control in pregnant women with GDM on perinatal outcomes.Materials and methods: Pregnant women in the 8th to 31st week of gestation were randomly assigned to 2 groups per target glycaemic levels: GDM1 (very tight glycaemic targets, fasting blood glucose (...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by varying combinations of endocrine tumors and commonly accompanying hyperplasia within the parathyroid gland, anterior pituitary and gastrointestinal tract. Heterozygous germline mutation of the tumor suppressor gene MEN1 is the most common cause of the disease. Molecular genetic testing of menin gene, in which mutation is known to cause MEN1 syndrome, detects pathogenic...

Introduction: Information regarding eating disorders (ED) in postsurgical outcomes after bariatric surgery (BS) is scarce.Objectives: To analyze the effect of BS on ED and to investigate if ED influence clinical, biochemical or psychological outcomes.Methods: Sixty patients (78.3%♀, age 46.35±9.89, months since BS 46.28±28.1) who underwent BS, with a minimum follow up of 12 months, were evaluated cross-sectionally. ...