Endocrine Abstracts

Introduction: Previous studies reported significant associations of steroid hormones with anthropometric parameters including body-mass-index (BMI) and waist circumference, as well as with some metabolic parameters such as triglycerides.Methods: 48 reproductive age males (age 18–49) were included in the study (27 obese individuals, 12 persons with excess body weight, 9 normal weight controls). We have examined the association between circulating st...

Objective: Sustained weight loss is a highly effective strategy to treat and prevent the development of type 2 diabetes (T2D). Bariatric surgery leads to significant weight loss, which ensures the achievement of remission of diabetes mellitus and other obesity-related comorbidities. AimThe aim of this study was to estimate glycemic profile of patients with morbid obesity and T2D after laparoscopic mini-gastric bypass (LMGB). MethodsWe conducted a retrospective study of ob...

Introduction: Autosomal recessively inherited disorders in the metabolism of mitochondrial fatty acid β-oxidation (FAO) constitute a group of rare diseases with different clinical manifestations and prognosis depending on the type of enzyme deficiency. Hypoketotic hypoglycemia is common to all these types of disorders and is associated with increased consumption of glucose and impaired synthesis of ketone bodies from fatty acids during the fasting periods, infection, or p...

Objective: To determine the incidence of endometrium pathology in women with autoimmune thyroid pathology and history of reproductive losses, including an assessment of histological images and immunohistochemical (IHC) analysis of the endometrial receptor status.Materials and methods: A prospective cohort study included a clinical and instrumental examination of 84 women aged 18 to 45 years with a history of 1 to 3 consecutive pregnancy losses. Patients ...

Introduction: Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) are common diseases among middle-aged and elderly persons. Aim of our study was to assess the influence of diabetic polyneuropathy (DPN) on the severity of pain in OA in patients with concomitant T2DM.Methods: 80 female patients with OA of the knee joints in combination with T2DM were examined. The severity of gonarthrosis were assessed by Lequesne index (IL) (version 1997) using a val...

The aim: To evaluate the efficiency and safety of using closed loop systems in patients with type 1 DM living in Russia.Results: 88 respondents (or those legal representatives) with type 1 DM in insulin therapy by closed loop systems, members of Russian-speaking community, were included to the study. 90% of respondents living in Russia. All respondents using do-it-yourself artificial pancreas systems (DIYAPS): Loop (19.3%), Open APS (30.7%) and Andr...

Aim of the study: to assess the interaction between TSH and the most common geriatric syndromes in the cohort of centenarians Materials and Methods: It was a longitudinal study, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and МOCA scores. We analyzed the interactions between TSH, m...

Aim of the study: To assess the most important metabolic factors in centenarians and their impact on mortality and prognosisMaterials and methods: Itwasalongitudinalstudy, including 82 centenarians (95 years and older), who live in Moscow. Complex geriatric assessment and blood tests were performed. Complex geriatric assessment included past medical history, FRAIL, IADL-C, MNA, GDS-15 and MOCA scores. We also analyzed levels of HbA1c, cholesterol, LDL, H...

Context: Autoimmune thyroid pathology can lead to serious complications of pregnancy and can be combined with generalized autoimmune imbalance, in particular, in the endometrium. The imbalance in the regulation of the immunocompetent cells activity and the increase of cytokines production are one of the reasons for the failed implantation or disruption of embryo development with future consequencesObjective: To assess the role of paracrine factors (expre...

The complex study of the endometrium, in particular, immunohistochemical (IHC), allows to determine the state of steroid receptivity and allows to choose the optimal way of examination in women with autoimmune thyroid diseases and miscarriages.Aim: To evaluate IHC expression of steroid receptors (ERα, ERβ, PR) in endometrium in women with a history of reproductive loss and autoimmune thyroid diseasesMaterials and methods:...