Endocrine Abstracts

Background: Patients with pituitary tumour live with life-long consequences of their disease. The first year after pituitary surgery represents a time period of symptoms, fear of tumour recurrence, existential concerns as well as extensive medical evaluations and decisions about hormone replacement. To increase wellbeing, a person-centred care practice up to 1 year after pituitary surgery covering self-management support, accessibility and continuity has been implemented and a...

Introduction: Antidepressants especially SSRI are widely used in all ages. Increase in serotonin level is not supposed to give side effects in other hormonal systems. Here we present a case with serotonergic like symptoms, elevated aldosterone levels and hypertension due to sertraline treatment.Clinical Case: A 37-year-old woman with previous PCÓs was admitted due to hypertension and high aldosterone. She had undergone two pregnancies after letrozol...

Phaeochromocytoma is an extremely rare cause of gestational hypertension. Failure to diagnose the condition can be catastrophic to both mother and foetus, therefore an early diagnosis and close co-operation between physicians, obstetricians and anaesthetists is essential.We present the case of a 24 year old woman, who was referred to her local maternity hospital at 34 weeks gestation as she was small for dates. Clinical examination was unremarkable, and ...

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

Background/aims: Oxidative stress and inflammation play a role in development of diabetic kidney disease. Postprandial hyperglycemia and hyperlipidemia are speculated to be associated with increased oxidative stress and inflammation. The aim was to examine the effect of meal composition on post-prandial risk markers for kidney disease among those with type 2 diabetes (T2D) and healthy subjects (HS).Material/methods: On four occasions 21 patients with T2D...

Introduction: Condition of injected skin and subcutaneous tissue is assessed by visual inspection and palpation and it has only 10–15% diagnostic value. The standard ultrasonography comparison of symmetrical skin areas is not valuable as they are usually used for injections.Objective: We examined 143 patients, aged 43.3 ± 3.9 years, with DM duration of 6.5 ± 2.8 years, receiving basal-bolus insulin therapy.Methods: ...

It is well established that thyroid hormones (TH) possess the ability to regulate body temperature. Thermogenesis can be induced peripherally in fat and muscle, but the active hormone T3 can also act centrally in the brain to raise the body temperature via the sympathetic nervous system. In recent studies, T3 treatment in mice has been shown to elevate the body temperature even far below thermoneutrality. This indicates that the induced hyperthyroidism causes a state of pyrexi...