Endocrine Abstracts

Background and aims: DIACAM1 study was designed to investigate the clinical characteristics of a representative group of type 1 diabetic (T1D) population in Castilla-La Mancha (Spain). The aim of this report is to describe the prevalence of microvascular complications and the factors associated with such complications.Materials and methods: This is an observational, cross-sectional, prospective and multicentre study of 1465 patients who received assistan...

Background: Thyroid hormones increase both serum levels of cystatin C and renal glomerular filtration rate (reflected by lower serum creatinine); the latter is considered the main determinant of cystatin C levels. A potential explanation for this apparently discrepant finding is an increased production, rather than a decreased clearance, of cystatin C. To study whether 3,3′,5-triiodo-L-thyronine (T3) increases the production of cystatin C in a w...

Aims/hypothesis: Several data have shown the association between diabetes type 2 (DM2) and transcription factor 7-like 2 (TCF7L2) gene polymorphisms, in several and different ethnical populations. Although the pathophysiology is not completely clear, it seems that beta and alpha cell functions are abnormal. Up to these days there is no clinical data showing association between TCF7L2 gene polymorphism allele rs7903146 T and beta cell insulin and C-peptide contents in DM2 patie...

Background: IGF-1 is a ubiquitous growth factor that has been shown to play an important role in breast tissue development and tumorigenesis. Previously we have shown that IGF-1 expression is lost in approximately 1/3 of breast carcinomas. It is unsure whether this indicates the existence of a subset of breast cancers that may behave differently clinically and on a molecular level. Aims: To assess and quantify the mRNA expression of (i) Cox-2 and c-myc, genes imp...

It has been reported that Ang II induces the growth of MCF-7 breast cancer cells (Muscella et al., J Endocrinol 173, 315-323, 2002). Here we have examined the signalling pathways evoked by Ang II in MCF-7. Ang II did not change the concentration of intracellular calcium but induced the cytosol-to-membrane translocation of atypical protein kinase C zeta (PKC-zeta). Ang II dose-dependently induced c-fos (mRNA and protein) and enhanced the phosphorylation state of extracellular s...

Background: PCO is more prevalent among SA than C and IR is central to its pathogenesis; whilst Type 2 diabetes (DM) is commoner in SA. We compared the phenotype and IR in South Asian and Caucasians with PCOS.Methods: Comparison of consecutive anovular PCOS; 47 SA and 36 Caucasians and their age and weight matched controls (11 SA and 22 Cs).Results: SA presented earlier (age 26 plus/minus 4 v 30.1 plus/minus 5, p = 0.005). BMI (24....

Interferon alpha (IFNα) and Ribavirin combination therapy effectively eradicates Hepatitis C Virus (HCV) in up to 80% of patients. Transient thyroid dysfunction (TD) (>80% hypothyroidism) usually due to a destructive thyroiditis has been recognised to occur in up to 25% of patients treated in Italy, Japan and Australia. However, data are lacking in a UK cohort and no standardised protocol for testing of thyroid function testing exists. The aim of this study was to det...

Introduction: Medullary thyroid carcinoma (MTC) and C cell hyperplasia (CCH) have a variable clinical presentation and prognosis and few data are available on the correlation between immunohistochemical characterization (IIC) and clinical behavior.Aim: We studied the clinical and morphological characterization of CCH and MTC and we evaluated IIC expression of PTTG-1, SSTR2A, VEGFR-1, VEGFR-2 and VEGFR-3 in 23 cases of CCH and/or MTC, correlating it with ...

Diabetes Mellitus (DM) has been associated with lung dysfunction and impairment of cardiorespiratory fitness and increasing evidences have suggested that comorbidities and systemic inflammation may be involved in these derangements. However, the results regarding cardiopulmonary dysfunction and its underlying mechanisms in DM are still controversial. In this study, we evaluated the relationship between metabolic variables and inflammation marker, including hemoglobin A1C (HbA1...

Introduction: E2F1 regulates the expression of genes required for cell cycle progression and apoptosis. miR-17-5p regulates expression of E2F1. Both miR-17-5p and E2F1 have been described deregulated in cancer but they have been scarcely studied in human pituitary neuroendocrine tumours (PitNETs).The aim of the present study was to find biomarkers of aggressiveness in PitNETs and report the correlation between E2F1 and...