Endocrine Abstracts

Introduction: Thyroid cancer is the most common malignant endocrine tumour and represents 1% of all malignancies. Cancer Research UK in 2015 reported 3528 new cases and 382 deaths with annual incidence of 5.1 and 1.9 per 100,000 women and men respectively. The incidence is increasing globally, mostly due to papillary thyroid cancer.Ultrasound is the preferred examination with recommended U1-U5 grading system +/- fine-needle aspiration cytology (FNAC)...

Objectives: The TNM classification is a worldwide benchmark for reporting the extent of malignant disease and is intended as a prognostic tool to predict the outcome in patients with cancer. Until 2004, no TNM classification was available for adrenocortical carcinoma (ACC) and different staging systems were used. Due to the rarity of this malignancy, the prognostic value of different staging systems has never been compared directly in a large series of patients.<p class="a...

Type 2 diabetes (T2D) is a debilitating, multifactorial disease with a complex mix of genetic and environmental pathomechanisms. For this reason, effective treatment of T2D requires a varied arsenal of therapeutic strategies and indeed, it is an excellent candidate for precision medicine. Essential for this, we need a more detailed understanding of the genetic drivers and how these differ between individuals. There is an ever-intensifying global effort to identify genetic asso...

Angiogenesis is a crucial physiological phenomenon in female reproductive cycle. Our previous studies have shown that progesterone could inhibit proliferation of human umbilical vein endothelial cells (HUVEC) through a p53-dependent mechanism, by which the levels of p21 and p27 protein were increased, subsequently inhibiting the CDK2 kinase activity, and finally impaired the transition of the cell from the G1 phase to the S phase. While previous studies had clearly demonstrate...

Background: Selenium is an important trace element for thyroid hormone metabolism and its deficiency can cause hypothyroidism. Serum or plasma selenium concentration has been known as best biomarker which reflects selenium intake and reserve. We preliminarily assessed the serum or urine selenium concentrations in patients with thyroid disease compared to healthy normal population. We also investigated the correlation of serum selenium concentration with urine selenium concentr...

Aim: Auger electron (AE)-emitting radionuclides are well suited as molecularly targeted radionuclide therapeutics (MRT) due to the high energy deposition density in the immediate vicinity of the decay site which avoids to a large extent non-specific radiotoxicity. However, due to the short range of the low-energy Auger (and Coster-Kronig) electrons, it is imperative that the AE emitting agent is closely associated with the cell nucleus. In this study we evaluate the dose depos...

Background: In recent years, continuous glucose monitoring (CGM) has emerged as a method for the assessment of glycemic control. Also CGM enables diabetic patients to understand their own blood glucose status and change their lifestyle.Aims: We investigated the effect of CGM on the glycemic control in Korean type 2 diabetic patients.Methods: We enrolled type 2 diabetic patients who met all the following criteria: 1) use of oral ant...

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This study was performed to investigate the effects of LY2405319, an analogue of fibroblast growth factor 21 (FGF21), on glucose homeostasis in streptozotocin (STZ)-induced insulin-deficient mice. Nine-week-old male C57BL/6J mice were administered a single intraperitoneal injection of STZ (150 mg/kg). One week later, after confirmation of hyperglycaemia, saline or LY2405319 (5 mg/kg) was injected subcutaneously daily for 4 weeks. The STZ-induced diabetic mice had elevated bloo...

Background: To predict severe acute pancreatitis (AP) at early stage is important to reduce morbidity and mortality. We aimed to investigate the association between the triglyceride and glucose index (TyG index) and the prognosis of acute pancreatitis.Methods: The TyG index was calculated as the ln[fasting triglycerides (mg/dl) × fasting plasma glucose (mg/dl)]/2. Patients were then categorized into low TyG index group (<5) and high TyG index gr...