Endocrine Abstracts

Background: Primary hyperparathyroidism (PHPT) is nowadays an asymptomatic disease characterized by mild hypercalcemia and elevated parathormone (PTH) levels. A non-typical form of the disease distinguished by high PTH levels, normal serum calcium concentrations, and no evidence of secondary hyperparathyroidism was recently identified. The data about parathyroid imaging findings in the normocalcemic type of the disease are lacking. Ultrasonography (US) is the most convenient i...

Introduction: Osteoporosis is a serious problem all over the world. The presence of low-energy fractures increases the risk of repeated fractures twice. Each new fracture increases the risk of a fatal outcome in the future. Globally, the most effective model of re-fractures preventing in patients with osteoporosis is a Fracture Liaison Service (FLS). FLS main objectives are identification of patients, assessment of re-fractures risks, diagnosis and initiation of osteoporosis t...

Introduction: Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) are common diseases among middle-aged and elderly persons. Aim of our study was to assess the influence of diabetic polyneuropathy (DPN) on the severity of pain in OA in patients with concomitant T2DM.Methods: 80 female patients with OA of the knee joints in combination with T2DM were examined. The severity of gonarthrosis were assessed by Lequesne index (IL) (version 1997) using a val...

Purpose: To assess the influence of diabetic polyneuropathy (DPN) on the course of chronic venous insufficiency (CVI) of the lower limbs in patients with combined pathology.Methods: 40 patients with CVI of the lower limbs in combination with diabetes mellitus (DM) type 2 were examined. DPN was diagnosed in 34 patients - group 1, 6 patients had no DPN - group 2. The diagnosis of CVI was established according to the international classification of CEAP. Th...

Introduction: Publications suggesting that thyroid nodules might be associated with insulin resistance (IR) and metabolic syndrome are quite interesting. The aim of the work is to analyze the association between anthropometric indicators IR and insulin-like growth factor-1 (IGF-1) in patients with nodular goiter. Methods Examined 73 patients with euthyroid single-node (n=34) and multinodular goiter (n=39), age (51.0±10.6) years; determinin...

Objective: Thyroid nodules are the most common thyroid disease and preoperative differentiation of benign and malignant lesions is an important diagnostic purpose. In about 1/3 cases FRA and cytological examination shows indeterminate diagnosis. Deregulation of miRNA expression has been described in a variety of tumors, including thyroid cancer. The aim of our study is to evaluate the association between miRNAs expression and risk of thyroid cancer in patients with thyroid nod...

Introduction: We report the clinical presentation, immunohistochemistry, imaging, histopathology, treatment and outcome of a patient with ACTH-secreting tumour of liver.Case report: Cushing’s Syndrome due to ectopic ACTH production is uncommon and due to neuroendocrine tumour of liver is extremely rare. We discuss the case of a 27-year-old female who initially presented with vague, non-specific symptoms, such as general and muscle weakness, weight g...

Introduction: Ectopic ACTH syndrome (EAS) is a rare cause of ACTH-dependent endogenous hypercortisolism.Objective: The objective of this study was to analyse the clinical, biochemical, and radiological features, management, and treatment outcome of patients with EAS.Design: It was a retrospective case-record study of 52 patients with EAS.Materials and methods: Clinical, biochemical, and radiological features ...

Background: The benefit of testosterone replacement therapy in men with hypogonadism nd metabolic syndrome is known. Safety of testosterone therapy is still a question of a high interest, especially regarding influence on cardiovascular system.Objective: To study the safety of testosterone therapy in hypogonadal men with metabolic syndrome based on cardiac ultrasound data.Methods: We studied 39 men aged 35–69 with hypogonadism...

Diabetes mellitus (DM) is accompanied with a variety of metabolic changes in different systems including bone. In several previous studies it was shown that DM type 1 is associated with a decreased mineral density, whereas the data regarding DM type 2 are still controversial.In the present study we examined the risk of different bone fractures in diabetic patients visiting local trauma clinic during one year (total area population 50.500). The incidence ...